{{Rsnum
|rsid=627928
|Gene=RNASEL
|Chromosome=1
|position=182582202
|Orientation=minus
|ReferenceAllele=T
|MissenseAllele=G
|GMAF=0.4743
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=RNASEL
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 33.6 | 51.3 | 15.0
| HCB | 56.6 | 36.8 | 6.6
| JPT | 47.8 | 35.4 | 16.8
| YRI | 4.8 | 42.2 | 53.1
| ASW | 10.5 | 49.1 | 40.4
| CHB | 56.6 | 36.8 | 6.6
| CHD | 56.0 | 37.6 | 6.4
| GIH | 30.7 | 45.5 | 23.8
| LWK | 0.9 | 26.9 | 72.2
| MEX | 24.1 | 43.1 | 32.8
| MKK | 11.5 | 41.0 | 47.4
| TSI | 21.6 | 57.8 | 20.6
| HapMapRevision=28
}}

{{Venter SNP
|rsid=627928
|allele=C
|frequency=0.375
|uid=1103675278107
|type=heterozygous_SNP
|hugo=RNASEL
|ensembl gene=ENSG00000135828
|ensembl transcript=ENST00000258306
|sift=
|disease=Defects in RNASEL may be the cause of susceptibility to hereditary prostate cancer 1 (HPC1) (MIM:176807, 601518).
}}

{{PMID Auto
|PMID=18575592
|Title=Germline mutation in RNASEL predicts increased risk of head and neck, uterine cervix and breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19567509
|Title=Genetic variants and prostate cancer risk: candidate replication and exploration of viral restriction genes.
|OA=1
}}

{{GET Evidence
|gene=RNASEL
|aa_change=Asp541Glu
|aa_change_short=D541E
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs627928
|overall_frequency_n=5108
|overall_frequency_d=10758
|overall_frequency=0.474809
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-2
|autoscore=2
|n_web_uneval=10
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}