{{Rsnum
|rsid=6295
|Gene=HTR1A
|Chromosome=5
|position=63962738
|Orientation=minus
|GMAF=0.4789
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=HTR1A
}}{{PMID Auto
|PMID=19358877
|Title=Imaging Phenotypes of Major Depressive Disorder: Genetic Correlates
|OA=1
}}
{{PMID Auto
|PMID=19326813
|Title=A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers
}}
{{PMID Auto
|PMID=19560507
|Title=Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder
}}
{{PMID Auto
|PMID=19725031
|Title=Significant association between the C(-1019)G functional polymorphism of the HTR(1A) gene and impulsivity
}}
{{PMID Auto
|PMID=19590397
|Title=5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression
}}
{{PMID Auto
|PMID=19894072
|Title=A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
}}

{{PharmGKB
|RSID=rs6295
|Name_s=
|Gene_s=HTR1A
|Feature=
|Evidence=PubMed ID:19800133
|Annotation=Risk or phenotype-associated allele(s): G/G. Phenotype: This SNP was strongly associated with response to treatment, in which 20 subjects with the GG genotype showed minimal changes in panic attack frequency with a relative risk of no response of 4.73. Study size: 102. Study population/ethnicity: patients with a diagnosis of panic disorder receiving sertraline or paroxetine.
|Drugs=
|Drug Classes=ANTIDEPRESSANTS
|Diseases=Panic Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA165109719
}}
{{PMID Auto
|PMID=20043001
|Title=Risk-Taking Behavior in a Gambling Task Associated with Variations in the Tryptophan Hydroxylase 2 Gene: Relevance to Psychiatric Disorders
|OA=1
}}
{{PMID Auto
|PMID=19897250
|Title=An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population
}}
{{PMID Auto
|PMID=19730445
|Title=Serotonin 1A receptor gene and major depressive disorder: an association study and meta-analysis
}}
{{PMID Auto
|PMID=19747927
|Title=Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients
}}
{{PMID Auto
|PMID=20594600
|Title=Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis
}}

{{PharmGKB
|RSID=rs6295
|Name_s=
|Gene_s=HTR1A
|Feature=
|Evidence=PubMed ID:18484082
|Annotation=The variant in the HTR1A gene has been found to affect the expression and function of HTR1A. rs6295 is in strong linkage disequilibrium with other polymorphisms of HTR1A. A study, investigating the response of SSRI in 137 Japanese major depression subjects, observed a significant association of better response to antidepressant in rs10042486 (P < 0.0001), rs6295 (P < 0.0001) and rs1364043 (P = 0.018) genotype carriers (minor allele homozygotes), independently from clinical variables.
|Drugs=fluvoxamine; paroxetine
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA161748486
}}

{{PharmGKB
|RSID=rs6295
|Name_s=
|Gene_s=HTR1A
|Feature=
|Evidence=PubMed ID:18047755; PubMed ID:18387740
|Annotation=This study provides preliminary support for poor treatment response mediated by the HTR1A-1019C allele repressing the receptor activity specifically in the melancholic subtype of depression. Contrary to this results a review article summarized that C allele carriers of this variant generally show a better response to treatment, especially in Caucasian samples.
|Drugs=
|Drug Classes=ANTIDEPRESSANTS
|Diseases=Depressive Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA164934775
}}

{{PharmGKB
|RSID=rs6295
|Name_s=HTR1A: -1019C/G
|Gene_s=HTR1A
|Feature=
|Evidence=PubMed ID:18639564
|Annotation=This review suggests that Gene-gene interaction studies suggest that the HTR1A G(-1019) allele is a risk allele which could be used as a marker for depression and related mood disorders.
|Drugs=
|Drug Classes=
|Diseases=Depressive Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA164934774
}}

{{PMID Auto
|PMID=21449006
|Title=Role of COMT, 5-HT(1A) , and SERT genetic polymorphisms on antidepressant response to transcranial magnetic stimulation
}}

{{PMID Auto
|PMID=21619616
|Title=Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness
|OA=1
}}

{{PMID Auto
|PMID=22232550
|Title=Deaf-1 knockout mice display increased 5-HT1A autoreceptor expression and reduced raphe serotonin levels
|OA=1
}}

{{PMID Auto
|PMID=22826341
|Title=Transcriptional regulation of the 5-HT1A receptor: implications for mental illness
|OA=1
}}
{{PMID Auto
|PMID=16626484
|Title=The serotonin 1A receptor C(-1019)G polymorphism in relation to suicide attempt.
|OA=1
}}

{{PMID Auto
|PMID=17192951
|Title=HTR2C and HTR1A gene variants in German and Italian suicide attempters and completers.
}}

{{PMID Auto
|PMID=18081710
|Title=Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
|OA=1
}}

{{PMID Auto
|PMID=18163385
|Title=Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders.
|OA=1
}}

{{PMID Auto
|PMID=18308786
|Title=The --1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients.
}}

{{PMID Auto
|PMID=18387137
|Title=5-HT1A receptor gene C -1019 G polymorphism and amygdala volume in borderline personality disorder.
}}

{{PMID Auto
|PMID=18715570
|Title=Serotonin receptor HTR1A and HTR2C variants and personality traits in suicide attempters and controls.
}}

{{PMID Auto
|PMID=18848359
|Title=The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population.
}}

{{PMID Auto
|PMID=19124686
|Title=Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety.
|OA=1
}}

{{PMID Auto
|PMID=19359258
|Title=Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
|OA=1
}}

{{PMID Auto
|PMID=19428959
|Title=5-HT(1A) receptor function in major depressive disorder.
|OA=1
}}

{{PMID Auto
|PMID=19829169
|Title=SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.
|OA=1
}}

{{PMID Auto
|PMID=19997044
|Title=No association between the serotonin-1A receptor gene single nucleotide polymorphism rs6295C/G and symptoms of anxiety or depression, and no interaction between the polymorphism and environmental stressors of childhood anxiety or recent stressful life events on anxiety or depression.
}}

{{PMID Auto
|PMID=20008943
|Title=Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
|OA=1
}}

{{PMID Auto
|PMID=20454985
|Title=Associations between the serotonin-1A receptor C(-1019)G polymorphism and disordered eating symptoms in female adolescents.
}}

{{PMID Auto
|PMID=20638825
|Title=The HTR1A and HTR1B receptor genes influence stress-related information processing.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21208417
|Title=International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol.
|OA=1
}}

{{PMID Auto
|PMID=21621273
|Title=Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report.
|OA=1
}}

{{PMID Auto
|PMID=22064163
|Title=Sertraline (Zoloft) response in major depressive disorder is not associated with three 5-HT1A receptor gene polymorphisms (rs6295, rs10042486, or rs1364043) in Chinese-Han patients.
}}

{{PMID Auto
|PMID=22392387
|Title=No association between the HTR1A gene and suicidal behavior: a meta-analysis.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6295
|overall_frequency_n=64
|overall_frequency_d=124
|overall_frequency=0.516129
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=57
|n_articles=3
|n_articles_annotated=2
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23192369
|Title=Relationship Between Genetic Polymorphisms in the HTR1A Gene and Paranoid Schizophrenia in a Northern Han Chinese Population
}}

{{PMID Auto
|PMID=23269215
|Title=Beyond Structural Equation Modeling: model properties and effect size from a Bayesian viewpoint. An example of complex phenotype - genotype associations in depression
}}

{{PMID Auto
|PMID=23798967
|Title=No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression
|OA=1
}}

{{PMID Auto
|PMID=23499153
|Title=Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy
}}

{{PMID Auto
|PMID=23318131
|Title=Association of serotonin-1A and -2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery
}}

{{PMID Auto
|PMID=24158751
|Title=The effect of serotonin 1A receptor polymorphism on the cognitive function of premenstrual dysphoric disorder
}}

{{PMID Auto
|PMID=24304270
|Title=Regulatory variant of the TPH2 gene and early life stress are associated with heightened attention to social signals of fear in infants
}}

{{PMID Auto
|PMID=22727709
|Title=Evaluation of genetic models for response in a randomized clinical trial of duloxetine in major depressive disorder.
}}

{{PMID Auto
|PMID=22752684
|Title=The serotonin 1A receptor gene confer susceptibility to mood disorders: results from an extended meta-analysis of patients with major depression and bipolar disorder.
}}

{{PMID Auto
|PMID=22890315
|Title=Association between the 5-HT1A receptor gene polymorphism (rs6295) and antidepressants: a meta-analysis.
}}

{{PMID Auto
|PMID=23036158
|Title=The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients.
}}

{{PMID Auto
|PMID=23333373
|Title=Rs6295 promoter variants of the serotonin type 1A receptor are differentially activated by c-Jun in vitro and correlate to transcript levels in human epileptic brain tissue.
}}

{{PMID Auto
|PMID=23375453
|Title=Genetic association of 5-HT1A and 5-HT1B gene polymorphisms with migraine in a Turkish population.
}}

{{PMID Auto
|PMID=23547754
|Title=Genetics of serotonin receptors and depression: state of the art.
}}

{{PMID Auto
|PMID=23733030
|Title=Pharmacogenetics in major depression: a comprehensive meta-analysis.
}}

{{PMID Auto
|PMID=25247748
|Title=Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}