{{Rsnum
|rsid=6313
|Gene=HTR2A
|Chromosome=13
|position=46895805
|Orientation=minus
|ReferenceAllele=C
|GMAF=0.4288
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HTR2A
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 27.4 | 52.2 | 20.4
| HCB | 22.6 | 44.5 | 32.8
| JPT | 25.7 | 48.7 | 25.7
| YRI | 41.5 | 44.9 | 13.6
| ASW | 30.4 | 50.0 | 19.6
| CHB | 22.6 | 44.5 | 32.8
| CHD | 13.8 | 55.0 | 31.2
| GIH | 36.6 | 49.5 | 13.9
| LWK | 48.2 | 42.7 | 9.1
| MEX | 36.2 | 51.7 | 12.1
| MKK | 55.8 | 38.5 | 5.8
| TSI | 22.5 | 52.0 | 25.5
| HapMapRevision=28
}}[[rs6313]], also known as T102C, is part of a 4-SNP haplotype in the serotonin 2A receptor gene [[HTR2A]] that has been associated with [[rheumatoid arthritis]] in a study of 1800 European patients. The risk allele is [[rs6313(C)]]. The overall risk for the haplotype CTCC of SNPs [[rs6311]]-[[rs1328674]]-[[rs6313]]-[[rs6314]] is 1.68 (CI: 1.20 - 2.34, p = 0.02). {{PMID|18006541}}

Note: the orientation of [[rs1328674]] in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.

see also [[gs108]] and [[gs226]]

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}}

{{PMID Auto
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|Title=5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression
}}

{{PharmGKB
|RSID=rs6313
|Name_s=HTR2A:T102C; HTR2A:102C>T
|Gene_s=HTR2A
|Feature=Exon/Syn
|Evidence=PubMed ID:19494443
|Annotation=Risk or phenotype-associated allele (s): T/T. Phenotype: Patients, with a diagnosis of probable Alzheimer&apos;s disease, carrying the TT genotype were the most delusional during the follow-up period of a study evaluating the association of HTR2A 102T/C polymorphism with psychotic symptom severity. Patients with delusion symptoms carrying the CT and TT genotypes were resistant to the treatment with antipsychotic drugs. Study size: 80. Study population/ethnicity: Caucasian
|Drugs=olanzapine; risperidone
|Drug Classes=
|Diseases=Alzheimer Disease
|Curation Level=Curated
|PharmGKB Accession ID=PA165109704
}}

{{PMID Auto
|PMID=19897250
|Title=An association study of the serotonin transporter and receptor genes with the suicidal ideation of major depression in a Chinese Han population
}}

{{PMID Auto
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{{PharmGKB
|RSID=rs6313
|Name_s=HTR2A:T102C; HTR2A:102C>T
|Gene_s=HTR2A
|Feature=Exon/Syn
|Evidence=PubMed ID:19193342
|Annotation=T allele is associated with olanzapine-induced weight gain
|Drugs=olanzapine
|Drug Classes=
|Diseases=Weight gain
|Curation Level=Curated
|PharmGKB Accession ID=PA164889040
}}
{{PMID Auto
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|Title=Rs 6313 polymorphism in 5-hydroxytryptamine receptor 2A gene association with polysymptomatic primary nocturnal enuresis
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|OA=1
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{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}