{{Rsnum
|rsid=6314
|Gene=HTR2A
|Chromosome=13
|position=46834899
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.06887
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=HTR2A
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 87.6 | 12.4 | 0.0
| HCB | 99.3 | 0.7 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 67.3 | 30.6 | 2.0
| ASW | 78.9 | 19.3 | 1.8
| CHB | 99.3 | 0.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 93.9 | 6.1 | 0.0
| LWK | 78.2 | 19.1 | 2.7
| MEX | 87.7 | 12.3 | 0.0
| MKK | 59.7 | 34.4 | 5.8
| TSI | 88.2 | 10.8 | 1.0
| HapMapRevision=28
}}[[rs6314]], also known as C1354T or His452Tyr/H452Y, is a SNP in the serotonin 2A receptor [[HTR2A]] gene.

Based on a study of 166 Caucasian patients being treated for [[depression]] with [[paroxetine]], [[rs6314]] heterozygotes were associated with better response. There was a significantly higher frequency of heterozygotes in the remitter and response groups in comparison to the non-remitter (odds ratio 7.50, p=0.002) and non-response groups (odds ratio 5.25, p=0.01).{{doi|10.1038/sj.tpj.6500491}}

* [[rs6314]] is part of a 4-SNP haplotype in the serotonin 2A receptor gene [[HTR2A]] that has been associated with [[rheumatoid arthritis]] in a study of 1800 European patients. The risk allele is [[rs6314(C)]]. The overall risk for the haplotype CTCC of SNPs [[rs6311]]-[[rs1328674]]-[[rs6313]]-[[rs6314]] is 1.68 (CI: 1.20 - 2.34, p = 0.02). {{PMID|18006541}}

Note: the orientation of [[rs1328674]] in dbSNP is opposite that cited by this publication; therefore, with respect to dbSNP, the haplotype of risk as cited above is CACC rather than CTCC.

{{PMID Auto
|PMID=19584773
|Title=Association between the serotonin 2A receptor gene and bipolar affective disorder in an Australian cohort
}}
: "Haplotype association analysis suggests that the haplotype CCGCA (at SNPs [[rs3125]], [[rs6314]], [[rs1923886]], [[rs2224721]] and [[rs2770296]]) is protective against [[bipolar disorder]] (P = 0.021, odds ratio 0.63) and the rarer haplotype CCACG confers risk to the disorder (P = 0.0065, odds ratio 3.08)."

{{PharmGKB
|RSID=rs6314
|Name_s=HTR2A: C1354T
|Gene_s=HTR2A
|Feature=
|Evidence=PubMed ID:11311507; PubMed ID:15052272; PubMed ID:18253134
|Annotation=In a study in a unipolar depressive population (n=166) this variant showed an association with remission and response following paroxetine therapy. HTR2A C1354T heterozygotes were significantly associated with improved response to paroxetine therapy. The SNP was also studied as a modifier of antidepressant response in a study in depressed patients (n=173) given a variety of antidepressant treatments with no association found, however another report found the HTR2A T1354 allele to be associated with response to fluoxetine.
|Drugs=fluoxetine; paroxetine
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA162181130
}}

{{PMID Auto
|PMID=19647026
|Title=Analysis of serotonin receptor 2A gene (HTR2A): association study with autism spectrum disorder in the Indian population and investigation of the gene expression in peripheral blood leukocytes
}}

Genetic variation in the serotonin 2A receptor and suicidal ideation in a sample of 270 Irish high-density [[schizophrenia]] families.{{PMID|18712714|OA=1
}}

{{PharmGKB
|RSID=rs6314
|Name_s=HTR2A: His452Tyr
|Gene_s=HTR2A
|Feature=
|Evidence=PubMed ID:14699448; PubMed ID:15891581; PubMed ID:18602445
|Annotation=This variant in the gene encoding the serotonin 2A receptor has been associated with human episodic memory performance and with differences in brain volume in memory-related brain regions.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA162181131
}}

{{PMID Auto
|PMID=16380908
|Title=Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder.
|OA=1
}}

{{PMID Auto
|PMID=16642433
|Title=Polymorphism in maternal LRP8 gene is associated with fetal growth.
|OA=1
}}

{{PMID Auto
|PMID=17000047
|Title=Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder.
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=18081710
|Title=Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.
|OA=1
}}

{{PMID Auto
|PMID=18611292
|Title=The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans.
}}

{{PMID Auto
|PMID=19077664
|Title=Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.
|OA=1
}}

{{PMID Auto
|PMID=19359258
|Title=Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.
|OA=1
}}

{{PMID Auto
|PMID=20008943
|Title=Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study.
|OA=1
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=22615781
|Title=Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study
|OA=1
}}

{{GET Evidence
|gene=HTR2A
|aa_change=His452Tyr
|aa_change_short=H452Y
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6314
|overall_frequency_n=1175
|overall_frequency_d=10758
|overall_frequency=0.109221
|n_genomes=14
|n_genomes_annotated=0
|n_haplomes=16
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|pph2_score=0.489
|nblosum100=-1
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23544600
|Title=Two Functional Serotonin Polymorphisms Moderate the Effect of Food Reinforcement on BMI
}}

{{PMID Auto
|PMID=23842608
|Title=Converging Evidence for the Association of Functional Genetic Variation in the Serotonin Receptor 2a Gene With Prefrontal Function and Olanzapine Treatment
}}

{{PMID Auto
|PMID=23808549
|Title=Candidate gene associations with withdrawn behavior.
}}

{{PMID Auto
|PMID=24968012
|Title=Serotonin 2A Receptor Gene (HTR2A) Regulatory Variants: Possible Association with Severity of Depression Symptoms in Children with Autism Spectrum Disorder
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}