{{Rsnum
|rsid=6323
|Gene=MAOA
|Chromosome=X
|position=43731789
|Orientation=plus
|GMAF=0.3319
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=MAOA
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 16.8 | 17.7 | 65.5
| HCB | 48.9 | 26.3 | 24.8
| JPT | 43.4 | 28.3 | 28.3
| YRI | 5.4 | 6.1 | 88.4
| ASW | 7.0 | 24.6 | 68.4
| CHB | 48.9 | 26.3 | 24.8
| CHD | 50.5 | 25.7 | 23.9
| GIH | 50.5 | 19.8 | 29.7
| LWK | 6.4 | 6.4 | 87.3
| MEX | 19.0 | 24.1 | 56.9
| MKK | 14.1 | 10.9 | 75.0
| TSI | 21.6 | 18.6 | 59.8
| HapMapRevision=28
}}[[rs6323]] (R297R / Arg297Arg) is a SNP in the [[MAOA]] (monoamine oxidase A) gene. Monoamine oxidase A degrades [[serotonin]], [[dopamine]], [[epineprine]], and [[norepinephrine]]. The G allele encodes for the higher activity form of the enzyme.

{{PMID Auto
|PMID=20691428
|Title=A cis-Phase Interaction Study of Genetic Variants Within the MAOA Gene in Major Depressive Disorder
}}

{{PMID|19593178}} Subjects with major depressive disorder with the highest activity form of the enzyme (G or G/G) had a significantly lower magnitude of placebo response.

{{PMID Auto
|PMID=21978760
|Title=Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese
|OA=1
}}

{{PMID Auto
|PMID=16174289
|Title=MAOA haplotypes associated with thrombocyte-MAO activity.
|OA=1
}}

{{PMID Auto
|PMID=17417058
|Title=Monoamine oxidase a gene is associated with borderline personality disorder.
}}

{{PMID Auto
|PMID=18180394
|Title=Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans.
|OA=1
}}

{{PMID Auto
|PMID=18501009
|Title=Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese.
|OA=1
}}

{{PMID Auto
|PMID=19693267
|Title=Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.
|OA=1
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21216270
|Title=Role of gene-gene/gene-environment interaction in the etiology of eastern Indian ADHD probands.
}}

{{PMID Auto
|PMID=21680027
|Title=Influence and interaction of genetic polymorphisms in catecholamine neurotransmitter systems and early life stress on antidepressant drug response.
}}

{{PMID Auto
|PMID=22162429
|Title=Study of a possible role of the monoamine oxidase A (MAOA) gene in paranoid schizophrenia among a Chinese population.
}}

{{PMID Auto
|PMID=23111930
|Title=MAOA and MAOB polymorphisms and anger-related traits in suicidal participants and controls
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}