{{Rsnum
|rsid=6330
|Gene=NGF
|Chromosome=1
|position=115286692
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.3058
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=NGF
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 29.5 | 52.7 | 17.9
| HCB | 75.2 | 22.6 | 2.2
| JPT | 64.3 | 33.9 | 1.8
| YRI | 69.4 | 29.9 | 0.7
| ASW | 70.2 | 26.3 | 3.5
| CHB | 75.2 | 22.6 | 2.2
| CHD | 72.5 | 23.9 | 3.7
| GIH | 64.4 | 26.7 | 8.9
| LWK | 72.7 | 25.5 | 1.8
| MEX | 31.0 | 58.6 | 10.3
| MKK | 63.5 | 34.6 | 1.9
| TSI | 32.4 | 45.1 | 22.5
| HapMapRevision=28
}}[[rs6330]] is a SNP causing a change in an amino acid in the nerve growth factor ([NGF]) gene, and based on this, it is also known as 104C>T or Ala35Val. The more common (C) allele encodes the alanine (Ala).

A study of 337 (age: 39.2 +/- 14.6 years) unrelated subjects of German descent found a significant (p=0.011) gender-dependent effect of this SNP on [[anxiety]] related personality traits. [[rs6330]](C;C) females had higher levels of trait anxiety than (C;T) or (T;T) females, while the opposite effect was seen in males.{{PMID|18763222}}

{{PMID Auto
|PMID=22330829
|Title=Possible influence of a non-synonymous polymorphism located in the NGF precursor on susceptibility to late-onset Alzheimer's disease and mild cognitive impairment.
}}

{{PMID Auto
|PMID=17192954
|Title=An investigation of the neurotrophic factor genes GDNF, NGF, and NT3 in susceptibility to ADHD.
}}

{{PMID Auto
|PMID=17212826
|Title=TAMGeS: a Three-array Method for Genotyping of SNPs by a dual-colour approach.
|OA=1
}}

{{PMID Auto
|PMID=18520591
|Title=Sequence variants in host cell factor C1 are associated with Meniere's disease.
|OA=1
}}

{{PMID Auto
|PMID=19063739
|Title=Genomic NGFB variation and multiple sclerosis in a case control study.
|OA=1
}}

{{GET Evidence
|gene=NGF
|aa_change=Ala35Val
|aa_change_short=A35V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6330
|overall_frequency_n=3985
|overall_frequency_d=10758
|overall_frequency=0.370422
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=41
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|pph2_score=0.123
|genetests_testable=Y
|nblosum100=2
|autoscore=2
|n_web_uneval=4
}}

{{PMID Auto
|PMID=23195334
|Title=Neurotrophin serum concentrations and polymorphisms of neurotrophins and their receptors in children with asthma
}}

{{PMID Auto
|PMID=23772677
|Title=Predicting outcomes following cognitive behaviour therapy in child anxiety disorders: the influence of genetic, demographic and clinical information.
}}

{{PMID Auto
|PMID=25162994
|Title=Sex-Specific Association Between Nerve Growth Factor Polymorphism and Cardiac Vagal Modulation
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}