{{Rsnum
|rsid=6356
|Gene=TH
|Chromosome=11
|position=2169721
|Orientation=minus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.4187
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TH
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 17.7 | 39.8 | 42.5
| HCB | 62.0 | 32.8 | 5.1
| JPT | 49.6 | 44.2 | 6.2
| YRI | 0.7 | 16.4 | 82.9
| ASW | 1.8 | 22.8 | 75.4
| CHB | 62.0 | 32.8 | 5.1
| CHD | 69.7 | 25.7 | 4.6
| GIH | 28.7 | 51.5 | 19.8
| LWK | 0.9 | 17.3 | 81.8
| MEX | 17.5 | 57.9 | 24.6
| MKK | 10.3 | 37.2 | 52.6
| TSI | 9.8 | 52.9 | 37.3
| HapMapRevision=28
}}{{PMID Auto
|PMID=19221445
|Title=Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits
}}

{{PMID Auto
|PMID=19772578
|Title=Two-stage case-control association study of dopamine-related genes and migraine
|OA=1
}}

{{ClinVar
|rsid=6356
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=2190951
|CHROM=11
|GMAF=0.418
|dbSNPBuildID=52
|SSR=0
|SAO=1
|VP=0x05016800000017051f100101
|GENEINFO=TH:7054
|GENE_NAME=TH
|GENE_ID=7054
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000011.9:g.2190951C>T
|CLNORIGIN=0
|CLNSIG=2
|Tags=RV;PM;PMC;SLO;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD
|CAF=0.5813; 0.4187
|CLNACC=RCV000021078.1
|CLNDBN=Segawa syndrome, autosomal recessive
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1437:C1854299:605407:101150
|CLNSRC=GeneReviews
|CLNSRCID=NBK1437
|COMMON=1
|Disease=Segawa syndrome
}}

{{PMID|15077008}} Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism.

{{PMID|17717598|OA=1
}} Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk.

{{PMID|17948905}} Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior.

{{PMID|18208403}} A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population.

{{PMID|19693267|OA=1
}} Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

{{PMID|19956101|OA=1
}} Overview of the Rapid Response data.

{{PMID|19956106|OA=1
}} Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families.

{{PMID|20016224}} Dopaminergic pathway gene polymorphisms and genetic susceptibility to schizophrenia among north Indians.

{{PMID|7789962}} Frequent sequence variant in the human tyrosine hydroxylase gene.

{{PMID|9754624}} Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism.

{{GET Evidence
|gene=TH
|aa_change=Val112Met
|aa_change_short=V112M
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6356
|overall_frequency_n=46
|overall_frequency_d=128
|overall_frequency=0.359375
|n_genomes=24
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=0
|n_articles_annotated=0
|qualityscore_in_silico=1
|qualitycomment_in_silico=Y
|gene_in_genetests=Y
|genetests_testable=Y
|genetests_reviewed=Y
|nblosum100=0
|autoscore=3
|n_web_uneval=10
}}

{{PMID Auto
|PMID=22560290
|Title=A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}