{{Rsnum
|rsid=63750215
|Chromosome=1
|Orientation=plus
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene=PSEN2
|position=226885603
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=PSEN2
}}{{omim
|id=600759
|rsnum=63750215
|variant=0001
}}

{{ClinVar
|rsid=63750215
|Reversed=0
|FwdREF=A
|FwdALT=T
|REF=A
|ALT=T
|RSPOS=226885603
|CHROM=1
|dbSNPBuildID=133
|SSR=0
|SAO=1
|VP=0x050168000a05000002110100
|GENEINFO=PSEN2:5664
|GENE_NAME=PSEN2
|GENE_ID=5664
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.226885603A>T
|CLNSRC=ClinVar; GeneReviews; Neurodegenerative Brain Diseases Group; OMIM Allelic Variant
|CLNORIGIN=1
|CLNSRCID=NM_000447.2:c.422A>T; NBK1236; ADM_51; 600759.0001
|CLNSIG=5
|CLNCUI=C1847200; C1847200
|CLNDBN=Alzheimer disease, type 4; not provided
|Disease=Alzheimer disease; not provided
|CLNACC=RCV000009393.2; RCV000084262.1
|Tags=PM;PMC;SLO;NSM;REF;ASP;OTHERKG;LSD;OM
|CLNDSDB=GeneReviews:MedGen:OMIM:Orphanet
|CLNDSDBID=NBK1236:C1847200:606889:ORPHA1020
}}

{{PMID Auto
|PMID=7638622
|Title=Candidate gene for the chromosome 1 familial Alzheimer's disease locus.
}}

{{PMID Auto
|PMID=7651536
|Title=Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene.
}}

{{PMID Auto
|PMID=9050898
|Title=The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue.
|OA=1
}}

{{PMID Auto
|PMID=9813158
|Title=Alzheimer's disease-linked mutation of presenilin 2 (N141I-PS2) drastically lowers APPalpha secretion: control by the proteasome.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}