{{Rsnum
|rsid=63750264
|Chromosome=21
|Orientation=minus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=APP
|position=25891784
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=APP
}}{{omim
|id=104760
|rsnum=63750264
|variant=0002
}}{{ClinVar
|rsid=63750264
|Reversed=1
|FwdREF=G
|FwdALT=A,C,T
|REF=C
|ALT=A,G,T
|RSPOS=27264096
|CHROM=21
|dbSNPBuildID=136
|SSR=0
|SAO=1
|VP=0x050168000000000102110104
|GENEINFO=APP:351
|GENE_NAME=APP
|GENE_ID=351
|WGT=0
|VC=SNV
|CLNALLE=1; 2; 3
|CLNHGVS=NC_000021.8:g.27264096C>A; NC_000021.8:g.27264096C>G; NC_000021.8:g.27264096C>T
|CLNSRC=OMIM Allelic Variant; GeneReviews; Neurodegenerative Brain Diseases Group
|CLNORIGIN=1; 0
|CLNSRCID=104760.0003; 104760.0021; NBK1236; ADM_90; 104760.0002
|CLNCUI=C1863052,C1863052,C1863052; C0002395
|CLNDBN=Alzheimer disease, type 1; Alzheimer's disease; not provided
|Disease=Alzheimer disease; Alzheimer's disease; not provided
|CLNACC=RCV000019715.26; RCV000019733.26; RCV000019714.25; RCV000020308.2; RCV000084575.1
|Tags=RV;PM;PMC;SLO;GNO;OTHERKG;LSD;OM;NOV
|CLNDSDB=MedGen; GeneReviews:GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C1863052; NBK1161:NBK1236:C0002395:104300:1020:26929004
|CLNSIG=5
}}{{PMID Auto
|PMID=1678057
|Title=Amyloid precursor protein gene mutation in early-onset Alzheimer's disease.
}}

{{PMID Auto
|PMID=1678058
|Title=Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
}}

{{PMID Auto
|PMID=1679288
|Title=APP717, APP693, and PRIP gene mutations are rare in Alzheimer disease.
|OA=1
}}

{{PMID Auto
|PMID=1908231
|Title=The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.
}}

{{PMID Auto
|PMID=8290965
|Title=Alzheimer's disease and possible gene interaction.
}}