{{Rsnum
|rsid=63750445
|Chromosome=21
|Orientation=minus
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene=APP
|position=27269939
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=132
|Status=Deleted
}}{{omim
|id=104760
|rsnum=63750445
|variant=0008
}}{{ClinVar
|rsid=63750445
|Reversed=1
|FwdREF=G
|FwdALT=T
|REF=C
|ALT=A
|RSPOS=27269939
|CHROM=21
|dbSNPBuildID=130
|SSR=0
|SAO=0
|VP=050168000a05000002110100
|GENEINFO=APP:351
|GENE_NAME=APP
|GENE_ID=351
|WGT=1
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000021.8:g.27269939C>A
|CLNSRC=OMIM Allelic Variant; GeneReviews
|CLNORIGIN=0
|CLNSRCID=104760.0008:104760.0018; NBK1236
|CLNSIG=5
|CLNCUI=C1863052; C0002395
|CLNDBN=Alzheimer disease, type 1; Alzheimer's disease
|Disease=Alzheimer disease; Alzheimer's disease
|CLNACC=SCV000040018.1; SCV000040680.1
|Tags=RV;PM;PMC;SLO;NSM;REF;ASP;OTHERKG;LSD;OM
}}{{PMID Auto
|PMID=88
|Title=The oxygen affinity of haemoglobin Tak, a variant with an elongated beta chain.
}}

{{PMID Auto
|PMID=1302033
|Title=A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.
}}

{{PMID Auto
|PMID=1465129
|Title=Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production.
}}

{{PMID Auto
|PMID=7489411
|Title=The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway.
}}

{{PMID Auto
|PMID=8012386
|Title=Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation.
}}

{{PMID Auto
|PMID=9371838
|Title=Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology.
|OA=1
}}

{{PMID Auto
|PMID=9796810
|Title=Neuron loss in APP transgenic mice.
}}