{{Rsnum
|rsid=63750671
|Chromosome=21
|Orientation=minus
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene=APP
|position=25891858
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=APP
}}{{omim
|id=104760
|rsnum=63750671
|variant=0005
}}

{{ClinVar
|rsid=63750671
|Reversed=1
|FwdREF=C
|FwdALT=G
|REF=G
|ALT=C
|RSPOS=27264170
|CHROM=21
|dbSNPBuildID=136
|SSR=0
|SAO=1
|VP=0x050168000000000002110100
|GENEINFO=APP:351
|GENE_NAME=APP
|GENE_ID=351
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000021.8:g.27264170G>C
|CLNSRC=GeneReviews; Neurodegenerative Brain Diseases Group; OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=NBK1236; ADM_56; 104760.0005
|CLNSIG=5
|CLNCUI=C1854045; C1863052; C0002395
|CLNDBN=Cerebral amyloid angiopathy, APP-related; Alzheimer disease, type 1; Alzheimer's disease; not provided
|Disease=Cerebral amyloid angiopathy; Alzheimer disease; Alzheimer's disease; not provided
|CLNACC=RCV000019717.26; RCV000019718.26; RCV000020306.2; RCV000084561.1
|Tags=RV;PM;PMC;SLO;OTHERKG;LSD;OM
|CLNDSDB=MedGen:OMIM:Orphanet:Orphanet; MedGen; GeneReviews:GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C2751536:605714:100006:85458; C1863052; NBK1161:NBK1236:C0002395:104300:1020:26929004
}}

{{PMID|1303239}} Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the beta-amyloid precursor protein gene.

{{PMID|9754958}} Presenile Alzheimer dementia characterized by amyloid angiopathy and large amyloid core type senile plaques in the APP 692Ala-->Gly mutation.

{{PMID|9848098}} Flemish and Dutch mutations in amyloid beta precursor protein have different effects on amyloid beta secretion.

{{PMID|11004129}} Presentation of amyloidosis in carriers of the codon 692 mutation in the amyloid precursor protein gene (APP692).

{{PMID|11311152|OA=1
}} In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease.

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}