{{Rsnum
|rsid=63750847
|Gene=APP
|Chromosome=21
|position=25897620
|Orientation=minus
|Summary=Alzheimer's related, 1% geno is good
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=APP
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}In [[APP]]

[http://www.molgen.ua.ac.be/ADMutations/Default.cfm?MT=1&ML=0&Page=Mutations&ID=160 source] Detected in 1 patient with 2 ischemic strokes and myocardial infarction. No family history; no amyloid deposition.

The variant also makes developing [[Alzheimer's disease]] four times less likely across all age groups. "It confers extraordinarily strong protection," said Stefansson. [http://www.reuters.com/article/2012/07/11/us-alzheimers-idUSBRE86A0WV20120711 source]

http://www.decodeyou.com/decode-genetics-discovers-mutation-conferring-protection-against-alzheimers-disease-and-cognitive-decline-in-elderly/

http://blog.personalgenomes.org/2012/08/01/the-predominant-variant-of-the-app-gene-greatly-increases-risk-for-alzheimers-disease-and-cognitive-decline/

{{ClinVar
|rsid=63750847
|Reversed=1
|FwdREF=G
|FwdALT=A
|REF=C
|ALT=T
|RSPOS=27269932
|CHROM=21
|dbSNPBuildID=137
|SSR=0
|SAO=0
|VP=0x050168000000000002100100
|GENEINFO=APP:351
|GENE_NAME=APP
|GENE_ID=351
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000021.8:g.27269932C>T
|CLNSIG=255
|Tags=RV;PM;PMC;SLO;OTHERKG;LSD
|CLNACC=RCV000030774.1; RCV000084558.1
|CLNDBN=Alzheimer disease, protection against; not provided
|CLNSRC=Neurodegenerative Brain Diseases Group; OMIM Allelic Variant
|CLNSRCID=ADM_160; 104760.0023
|Disease=Alzheimer disease; not provided
}}

{{PMID Auto
|PMID=23510020
|Title=Have we learnt all we need to know from genetic studies - is genetics over in Alzheimer's disease?
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}