{{Rsnum
|rsid=63751039
|Chromosome=21
|Orientation=minus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=APP
|position=25891855
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=APP
}}{{omim
|id=104760
|rsnum=63751039
|variant=0013
}}{{ClinVar
|rsid=63751039
|Reversed=1
|FwdREF=A
|FwdALT=G
|REF=T
|ALT=C
|RSPOS=27264167
|CHROM=21
|dbSNPBuildID=136
|SSR=0
|SAO=1
|VP=0x050168000000000002110100
|GENEINFO=APP:351
|GENE_NAME=APP
|GENE_ID=351
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000021.8:g.27264167T>C
|CLNSRC=GeneReviews; Neurodegenerative Brain Diseases Group; OMIM Allelic Variant
|CLNORIGIN=0
|CLNSRCID=NBK1236; ADM_96; 104760.0013
|CLNSIG=5
|CLNCUI=C1863052; C1854045; C0002395
|CLNDBN=Alzheimer disease, type 1; Cerebral amyloid angiopathy, APP-related; Alzheimer's disease; not provided
|Disease=Alzheimer disease; Cerebral amyloid angiopathy; Alzheimer's disease; not provided
|CLNACC=RCV000019725.26; RCV000019726.26; RCV000020307.2; RCV000084563.1
|Tags=RV;PM;PMC;SLO;OTHERKG;LSD;OM
|CLNDSDB=MedGen; MedGen:OMIM:Orphanet:Orphanet; GeneReviews:GeneReviews:MedGen:OMIM:Orphanet:SNOMED_CT
|CLNDSDBID=C1863052; C2751536:605714:100006:85458; NBK1161:NBK1236:C0002395:104300:1020:26929004
}}{{PMID Auto
|PMID=1415269
|Title=Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region.
|OA=1
}}

{{PMID Auto
|PMID=10821838
|Title=Substitutions at codon 22 of Alzheimer's abeta peptide induce diverse conformational changes and apoptotic effects in human cerebral endothelial cells.
}}

{{PMID Auto
|PMID=11528419
|Title=The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation.
}}

{{PMID Auto
|PMID=15502844
|Title=Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation.
}}

{{PMID Auto
|PMID=18413473
|Title=Clinical and neuropathological features of the arctic APP gene mutation causing early-onset Alzheimer disease.
|OA=1
}}