{{Rsnum
|rsid=6413413
|Gene=ADH1B
|Chromosome=4
|position=99318127
|Orientation=plus
|GMAF=0.007805
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=ADH1B
}}[[rs6413413]], also known as Thr60Ser, is a SNP in the alcohol dehydrogenase 1B [[ADH1B]] gene. The [[rs6413413]](A) allele is the more common, encoding the amino acid threonine (Thr); the quite rare [[rs6413413]](T) allele encodes the variant serine (Ser). 

On it's own, this SNP is said to explain 2.5% of the variability in the rate at which alcohol is metabolized, based on a study of 250 Spaniards.{{PMID|20101753}}

More significantly (in a statistical sense), this study concluded that combinations of this SNP and others were shown to affect alcohol metabolism; most of these combinations are represented by the [[gs211]]
genoset.

Note that the effects of alcohol are higher in individuals who break down (basically, detoxify) ethanol more slowly.

{{PMID Auto
|PMID=17355643
|Title=Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.
|OA=1
}}

{{GET Evidence
|gene=ADH1B
|aa_change=Thr60Ser
|aa_change_short=T60S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6413413
|overall_frequency_n=38
|overall_frequency_d=10758
|overall_frequency=0.00353226
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=1
|n_articles=0
|n_articles_annotated=0
|nblosum100=-2
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}