{{Rsnum
|rsid=6446482
|Gene=WFS1
|Chromosome=4
|position=6293966
|Orientation=plus
|GMAF=0.2741
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=WFS1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 3.1 | 43.1 | 53.8
| HCB | 0.0 | 8.9 | 91.1
| JPT | 0.0 | 2.3 | 97.7
| YRI | 9.5 | 36.5 | 54.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 8.9 | 91.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=19258739
|Title=Association study of the effect of WFS1 polymorphisms on risk of type 2 diabetes in Japanese population
}}

{{omim
|desc=DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM
|id=125853
|rsnum=6446482
}}

{{omim
|id=606201
|desc=WFS1 GENE; WFS1
|rsnum=6446482
}}

{{PharmGKB
|RSID=rs6446482
|Name_s=
|Gene_s=WFS1
|Feature=
|Evidence=PubMed ID:17603484
|Annotation=rs6446482 was found to be associated with Type 2 Diabetes risk in a case-control study of UK populations; the association was replicated in an Ashkenazi population.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162356067
}}

{{omim
|id=606201
|rsnum=6446482
|variant=0021
}}

{{omim
|id=606201
|rsnum=6446482
|variant=0022
}}

{{PMID Auto
|PMID=18040659
|Title=Replication of the association between variants in WFS1 and risk of type 2 diabetes in European populations.
|OA=1
}}

{{PMID Auto
|PMID=18060660
|Title=Testing of diabetes-associated WFS1 polymorphisms in the Diabetes Prevention Program.
|OA=1
}}

{{PMID Auto
|PMID=20509872
|Title=Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6446482
|overall_frequency_n=88
|overall_frequency_d=128
|overall_frequency=0.6875
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=76
|n_articles=2
|n_articles_annotated=2
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22996131
|Title=Monogenic models: what have the single gene disorders taught us?
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}