{{Rsnum
|rsid=6457617
|Chromosome=6
|position=32696074
|Orientation=plus
|GMAF=0.4389
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 22.1 | 51.3 | 26.5
| HCB | 24.1 | 46.0 | 29.9
| JPT | 15.0 | 46.9 | 38.1
| YRI | 30.6 | 51.0 | 18.4
| ASW | 26.8 | 35.7 | 37.5
| CHB | 24.1 | 46.0 | 29.9
| CHD | 13.8 | 57.8 | 28.4
| GIH | 24.8 | 57.4 | 17.8
| LWK | 17.3 | 50.0 | 32.7
| MEX | 6.9 | 41.4 | 51.7
| MKK | 27.6 | 50.0 | 22.4
| TSI | 19.6 | 50.0 | 30.4
| HapMapRevision=28
}}
[[rs6457617]] has been reported in a large study to be associated with [[rheumatoid arthritis]]. This SNP is reported to be the most statistically significant of many SNPs similarly located in the MHC region.

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 2.36 (CI 1.97-2.84), and for homozygotes, 5.21 (CI 4.31-6.30). {{PMID|17554300|OA=1
}}

{{PMID Auto GWAS
|PMID=18668548
|Trait=Rheumatoid arthritis
|Title=Genome-wide association study of rheumatoid arthritis in the Spanish population: KLF12 as a risk locus for rheumatoid arthritis susceptibility
|RiskAllele=
|Pval=1.0000000000000001E-9
|OR=NR
|ORtxt=NR
}}

{{PMID Auto
|PMID=19714643
|Title=TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
}}

{{PMID Auto GWAS
|PMID=20383147
|Trait=Systemic sclerosis
|Title=Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
|RiskAllele=
|Pval=4E-17
|OR=1.37
|ORtxt=[1.28-1.47]
|OA=1
}}

{{PMID Auto
|PMID=21750679
|Title=Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB as Novel Risk Loci for Systemic Sclerosis
|OA=1
}}

{{PMID Auto GWAS
|PMID=21841780
|Trait=None
|Title=A genome-wide association study identifies two new risk loci for Graves' disease.
|RiskAllele=T
|Pval=7E-33
|OR=1.4000
|ORtxt=[1.32-1.48]
}}

{{PMID Auto
|PMID=22355377
|Title=Caucasian and asian specific rheumatoid arthritis risk Loci reveal limited replication and apparent allelic heterogeneity in north indians
|OA=1
}}

{{PMID Auto
|PMID=17660530
|Title=Risk alleles for multiple sclerosis identified by a genomewide study.
}}

{{PMID Auto
|PMID=18204098
|Title=Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=19116921
|Title=Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
|OA=1
}}

{{PMID Auto
|PMID=19846760
|Title=Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases.
|OA=1
}}

{{PMID Auto
|PMID=20017963
|Title=Representation of genetic association via attributable familial relative risks in order to identify polymorphisms functionally relevant to rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20018025
|Title=Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium.
|OA=1
}}

{{PMID Auto
|PMID=20018049
|Title=Evaluation of an optimal receiver operating characteristic procedure.
|OA=1
}}

{{PMID Auto
|PMID=20018075
|Title=Genome-wide association study of rheumatoid arthritis by a score test based on wavelet transformation.
|OA=1
}}

{{PMID Auto
|PMID=20018081
|Title=Assessment of gene-covariate interactions by incorporating covariates into association mapping.
|OA=1
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=20426808
|Title=AntEpiSeeker: detecting epistatic interactions for case-control studies using a two-stage ant colony optimization algorithm.
|OA=1
}}

{{PMID Auto
|PMID=20546594
|Title=An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings.
|OA=1
}}

{{PMID Auto
|PMID=21739420
|Title=Genetic variants in the HLA-DRB1 gene are associated with Kashin-Beck disease in the Tibetan population.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6457617
|overall_frequency_n=67
|overall_frequency_d=122
|overall_frequency=0.54918
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=55
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}