{{Rsnum
|rsid=6458307
|Chromosome=6
|position=42763377
|Orientation=plus
|GMAF=0.3439
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 48.7 | 37.2 | 14.2
| HCB | 53.3 | 43.1 | 3.6
| JPT | 54.9 | 38.1 | 7.1
| YRI | 25.2 | 44.2 | 30.6
| ASW | 15.8 | 59.6 | 24.6
| CHB | 53.3 | 43.1 | 3.6
| CHD | 63.0 | 34.3 | 2.8
| GIH | 50.5 | 37.6 | 11.9
| LWK | 22.7 | 47.3 | 30.0
| MEX | 41.4 | 53.4 | 5.2
| MKK | 11.3 | 45.7 | 43.0
| TSI | 42.2 | 42.2 | 15.7
| HapMapRevision=28
}}[[rs6458307]] has been reported in a large study to be associated with [[bipolar disorder]].

The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 0.84 (CI 0.75-0.96), and for homozygotes, 1.39 (CI 1.13-1.69). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs6458307
|PubMedID=17554300
|Condition=Bipolar disorder
|Gene=NR
|Risk Allele=
|pValue=4.00E-006
|OR=1.19
|95CI=1.04-1.33
|OA=1
}}

{{PharmGKB
|RSID=rs6458307
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,868 cases, 2,938 controls; Replication Sample Size: NR). This variant is associated with Bipolar disorder.
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356506
}}

{{PMID Auto
|PMID=19308021
|Title=Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6458307
|overall_frequency_n=58
|overall_frequency_d=128
|overall_frequency=0.453125
|n_genomes=38
|n_genomes_annotated=0
|n_haplomes=47
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}