{{Rsnum
|rsid=6474413
|Gene=CHRNB3
|Chromosome=8
|position=42695921
|Orientation=plus
|GMAF=0.343
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CHRNB3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 5.3 | 34.5 | 60.2
| HCB | 8.8 | 38.0 | 53.3
| JPT | 0.9 | 23.9 | 75.2
| YRI | 60.5 | 34.7 | 4.8
| ASW | 49.1 | 38.6 | 12.3
| CHB | 8.8 | 38.0 | 53.3
| CHD | 4.6 | 31.2 | 64.2
| GIH | 4.0 | 39.6 | 56.4
| LWK | 50.9 | 40.9 | 8.2
| MEX | 1.7 | 27.6 | 70.7
| MKK | 41.0 | 45.5 | 13.5
| TSI | 2.0 | 31.4 | 66.7
| HapMapRevision=28
}}rs6474413 increases susceptibility to Substance dependence, Nicotine 1.35 times for carriers of the T allele {{PMID|17135278|OA=1
}}

{{PMID Auto
|PMID=19482438
|Title=Association of genes coding for the alpha-4, alpha-5, beta-2 and beta-3 subunits of nicotinic receptors with cigarette smoking and nicotine dependence
}}

{{PMID Auto
|PMID=17158188
|Title=Novel genes identified in a high-density genome wide association study for nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18565990
|Title=Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=18571741
|Title=Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.
|OA=1
}}

{{PMID Auto
|PMID=18704094
|Title=Genetic association of the CHRNA6 and CHRNB3 genes with tobacco dependence in a nationally representative sample.
|OA=1
}}

{{PMID Auto
|PMID=19029397
|Title=Nicotinic receptor gene variants influence susceptibility to heavy smoking.
|OA=1
}}

{{PMID Auto
|PMID=19184766
|Title=A testable prognostic model of nicotine dependence.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}