{{Rsnum
|rsid=6478108
|Gene=TNFSF15
|Chromosome=9
|position=114796423
|Orientation=plus
|GMAF=0.3072
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|effect1=
|effect2=
|effect3=
|Gene_s=TNFSF15
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 12.4 | 50.4 | 37.2
| HCB | 22.6 | 54.0 | 23.4
| JPT | 15.9 | 44.2 | 39.8
| YRI | 0.7 | 15.6 | 83.7
| ASW | 7.0 | 29.8 | 63.2
| CHB | 22.6 | 54.0 | 23.4
| CHD | 30.3 | 48.6 | 21.1
| GIH | 5.9 | 33.7 | 60.4
| LWK | 0.9 | 20.0 | 79.1
| MEX | 10.3 | 32.8 | 56.9
| MKK | 1.3 | 26.3 | 72.4
| TSI | 7.8 | 38.2 | 53.9
| HapMapRevision=28
}}Associated with increased risk for [[Crohn's disease]] in a study of 380 Korean patients.{{PMID|18422820}}

This SNP is associated with greater susceptibility to [[leprosy]] in Asians, according to the [http://blog.23andme.com/2009/12/16/snpwatch-genetic-association-study-of-leprosy-yields-new-insights-into-an-ancient-disease/ 23andMe blog]. The risk allele is T, and the odds ratio is 1.37.

The [[TNFSF15]] gene encodes a [[cytokine]] protein in the [[tumor necrosis factor]] ([[TNF]]) family.

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 16; IBD16
|id=612259
|rsnum=6478108
}}

{{PMID Auto GWAS
|PMID=20018961
|Trait=Leprosy
|Title=Genomewide Association Study of Leprosy
|RiskAllele=A
|Pval=3E-21
|OR=1.37
|ORtxt=[1.28-1.46]
}}

{{PMID|17663424|OA=1
}} TNFSF15 is an ethnic-specific IBD gene.

{{PMID|18758464|OA=1
}} Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.

{{PMID|19174806}} TNFSF15 polymorphisms are associated with susceptibility to inflammatory bowel disease in a new European cohort.

{{PMID|19262684|OA=1
}} IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.

{{PMID|19543369|OA=1
}} Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritis.

{{PMID|22684480}} Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFalpha

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6478108
|overall_frequency_n=97
|overall_frequency_d=128
|overall_frequency=0.757812
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

[[Leprosy Susceptibility]]

{{PMID Auto
|PMID=24269700
|Title=Genetic risk and protective factors of TNFSF15 gene variants detected using single nucleotide polymorphisms in Hungarians with psoriasis and psoriatic arthritis
}}

{{PMID Auto
|PMID=25028192
|Title=Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: A meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}