{{Rsnum
|rsid=6494696
|Chromosome=15
|position=67810868
|Orientation=plus
|GMAF=0.4931
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 4.5 | 48.2 | 47.3
| HCB | 48.2 | 46.7 | 5.1
| JPT | 52.2 | 38.1 | 9.7
| YRI | 20.4 | 51.0 | 28.6
| ASW | 24.6 | 42.1 | 33.3
| CHB | 48.2 | 46.7 | 5.1
| CHD | 47.7 | 42.2 | 10.1
| GIH | 26.7 | 43.6 | 29.7
| LWK | 15.5 | 49.1 | 35.5
| MEX | 37.9 | 48.3 | 13.8
| MKK | 10.3 | 42.9 | 46.8
| TSI | 13.9 | 40.6 | 45.5
| HapMapRevision=28
}}[[rs6494696]], a SNP located in a region of chromosome 15q, has been linked to a lower frequency of [[restless legs syndrome]], a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (C) minor allele. {{PMID|17637780}}

The association between this SNP and RLS has been replicated in three European populations.{{PMID|19279021|OA=1
}}

{{omim
|desc=RESTLESS LEGS SYNDROME, SUSCEPTIBILITY TO, 1
|id=102300
|rsnum=6494696
}}

{{PharmGKB
|RSID=rs6494696
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17637780
|Annotation=In replicated GWAS case-control studies of Caucasian(European and French-Canadian) familial and sporadic RLS, the G allele of rs6494696 was significantly associated with Restless Legs Syndrome.
|Drugs=
|Drug Classes=
|Diseases=Restless Legs Syndrome
|Curation Level=Curated
|PharmGKB Accession ID=PA162355634
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6494696
|overall_frequency_n=60
|overall_frequency_d=128
|overall_frequency=0.46875
|n_genomes=41
|n_genomes_annotated=0
|n_haplomes=56
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}