{{Rsnum
|rsid=6495306
|Gene=CHRNA5
|Chromosome=15
|position=78573551
|Orientation=plus
|GMAF=0.2764
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CHRNA5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 38.9 | 39.8 | 21.2
| HCB | 65.0 | 31.4 | 3.6
| JPT | 79.6 | 19.5 | 0.9
| YRI | 59.9 | 33.3 | 6.8
| ASW | 52.6 | 42.1 | 5.3
| CHB | 65.0 | 31.4 | 3.6
| CHD | 67.9 | 29.4 | 2.8
| GIH | 46.5 | 45.5 | 7.9
| LWK | 58.7 | 35.8 | 5.5
| MEX | 65.5 | 24.1 | 10.3
| MKK | 48.1 | 42.3 | 9.6
| TSI | 40.2 | 50.0 | 9.8
| HapMapRevision=28
}}

{{Report GE
|PubMed=18414406
|Source=journal
|AffyProbeset=SNP_A-8603150
|AffyOrientation=reverse
|AlleleA=C
|AlleleB=T
|onGW5=
|rsid=6495306
|ancestral=A
|RiskPopulation=mixed
|RiskAllele=G
|CaseFreq=
|ControlFreq=
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.43
|Disease=Substance dependence, Alcohol
|DiseaseSymbol=SD-A
}}

rs6495306 increases susceptibility to Substance dependence, Alcohol 1.43 times for carriers of the G allele {{PMID|18414406}}

{{PMID Auto
|PMID=19064933
|Title=Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans.
|OA=1
}}

{{PMID Auto
|PMID=19443489
|Title=Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
|OA=1
}}

{{PMID Auto
|PMID=19706762
|Title=The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}