{{Rsnum
|rsid=6495446
|Gene=MTHFS
|Chromosome=15
|position=79862640
|Orientation=plus
|GMAF=0.3058
|Gene_s=MTHFS,ST20-MTHFS
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 61.6 | 35.7 | 2.7
| HCB | 53.3 | 40.0 | 6.7
| JPT | 58.0 | 39.3 | 2.7
| YRI | 25.5 | 50.3 | 24.1
| ASW | 28.1 | 56.1 | 15.8
| CHB | 53.3 | 40.0 | 6.7
| CHD | 57.4 | 39.8 | 2.8
| GIH | 71.7 | 23.2 | 5.1
| LWK | 27.8 | 41.7 | 30.6
| MEX | 60.7 | 32.1 | 7.1
| MKK | 32.7 | 45.1 | 22.2
| TSI | 52.5 | 41.6 | 5.9
| HapMapRevision=28
}}
[[rs6495446]], an intronic SNP in the [[MTHFS]] gene, was associated with increased risk for [[chronic kidney disease]] based on a study associated with the Framingham Heart Study of ~1,000 Caucasian individuals. The odds ratio [[rs6495446]](C) allele was 1.24 (CI: 1.09-1.41, p=0.001).[http://7thspace.com/headlines/283295/genome_wide_association_study_for_renal_traits_in_the_framingham_heart_and_atherosclerosis_risk_in_communities_studies.html  news] 23andMe reports this same information with a different emphasis: each T allele lowers the odds of chronic kidney disease by 0.8 times. {{PMID|18522750|OA=1
}}

{{PMID Auto
|PMID=21895484
|Title=The impact of 5,10-methenyltetrahydrofolate synthetase polymorphism on diabetic nephropathy in the Taiwanese population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}