{{Rsnum
|rsid=6498169
|Gene=CLEC16A
|Chromosome=16
|position=11155472
|Orientation=plus
|GMAF=0.3972
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CLEC16A
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 37.5 | 45.5 | 17.0
| HCB | 20.4 | 51.1 | 28.5
| JPT | 18.8 | 50.0 | 31.2
| YRI | 64.6 | 29.3 | 6.1
| ASW | 50.0 | 46.4 | 3.6
| CHB | 20.4 | 51.1 | 28.5
| CHD | 0.0 | 0.0 | 0.0
| GIH | 59.0 | 34.0 | 7.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 19.0 | 43.1 | 37.9
| MKK | 69.9 | 23.7 | 6.4
| TSI | 48.0 | 38.0 | 14.0
| HapMapRevision=28
}}[[rs6498169]] has been reported in a large study to be associated with [[multiple sclerosis]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with this allele is 1.14 (CI 1.08-1.21). {{PMID|17660530}}

{{GWAS Summary
|SNP=rs6498169
|PubMedID=17660530
|Condition=Multiple sclerosis
|Gene=KIAA0350
|Risk Allele=G
|pValue=4.00E-006
|OR=1.14
|95CI=1.08-1.21
}}

{{PMID Auto
|PMID=19317741
|Title=Autoimmune disease association signals in CIITA and KIAA0350 are not involved in celiac disease susceptibility
}}

{{PMID Auto
|PMID=19734133
|Title=A CLEC16A variant confers risk for juvenile idiopathic arthritis and anti-CCP negative rheumatoid arthritis
|OA=1
}}
{{PMID Auto
|PMID=18650830
|Title=Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians
}}

{{PharmGKB
|RSID=rs6498169
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17660530; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Risk alleles for multiple sclerosis identified by a genomewide study (Initial Sample Size: 931 trios, 2,431 controls; Replication Sample Size: 609 trios, 2,322 cases, 2,987 controls; Risk Allele: rs6498169-G).
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356684
}}

{{PharmGKB
|RSID=rs6498169
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17660530
|Annotation=In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162356161
}}

{{omim
|id=126200
|rsnum=6498169
}}

{{PMID Auto
|PMID=18987646
|Title=The expanding genetic overlap between multiple sclerosis and type I diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19221398
|Title=Chromosomal region 16p13: further evidence of increased predisposition to immune diseases.
}}

{{PMID Auto
|PMID=19337309
|Title=Specific association of a CLEC16A/KIAA0350 polymorphism with NOD2/CARD15(-) Crohn's disease patients.
|OA=1
}}

{{PMID Auto
|PMID=20007504
|Title=Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.
|OA=1
}}

{{PMID Auto
|PMID=20211854
|Title=CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=20220768
|Title=A candidate gene study of CLEC16A does not provide evidence of association with risk for anti-CCP-positive rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20368992
|Title=Multiple sclerosis susceptibility-associated SNPs do not influence disease severity measures in a cohort of Australian MS patients.
|OA=1
}}

{{PMID Auto
|PMID=21179112
|Title=Exploring the CLEC16A gene reveals a MS-associated variant with correlation to the relative expression of CLEC16A isoforms in thymus.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6498169
|overall_frequency_n=87
|overall_frequency_d=128
|overall_frequency=0.679688
|n_genomes=49
|n_genomes_annotated=0
|n_haplomes=73
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23151489
|Title=Multiple sclerosis-associated single-nucleotide polymorphisms in CLEC16A correlate with reduced SOCS1 and DEXI expression in the thymus
}}

{{PMID Auto
|PMID=22492128
|Title=Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}