{{Rsnum
|rsid=6499640
|Gene=FTO
|Chromosome=16
|position=53735765
|Orientation=plus
|GMAF=0.483
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=FTO
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 42.5 | 43.4 | 14.2
| HCB | 2.9 | 27.7 | 69.3
| JPT | 4.4 | 28.3 | 67.3
| YRI | 46.9 | 40.1 | 12.9
| ASW | 36.8 | 54.4 | 8.8
| CHB | 2.9 | 27.7 | 69.3
| CHD | 6.4 | 31.2 | 62.4
| GIH | 24.8 | 43.6 | 31.7
| LWK | 43.6 | 46.4 | 10.0
| MEX | 13.8 | 43.1 | 43.1
| MKK | 21.8 | 50.0 | 28.2
| TSI | 38.2 | 49.0 | 12.7
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19079260
|Trait=Body mass index
|Title=Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
|RiskAllele=A
|Pval=4E-13
|OR=5.25
|ORtxt=[3.82-6.68] % SD
}}

{{PharmGKB
|RSID=rs6499640
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 16q12.2; Reported Gene(s): FTO; Risk Allele: rs6499640-A); (p-value= 0.00000000000006).This variant is associated with Weight.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740170
}}

{{PharmGKB
|RSID=rs6499640
|Name_s=
|Gene_s=FTO
|Feature=
|Evidence=PubMed ID:19079260; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. (Initial Sample Size: 80,969 individuals; Replication Sample Size: 11,036 individuals); (Region: 16q12.2; Reported Gene(s): FTO; Risk Allele: rs6499640-A); (p-value= 0.0000000000004).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740156
}}
{{PMID Auto
|PMID=20843981
|Title=Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children
|OA=1
}}

{{PMID Auto
|PMID=21527513
|Title=Influence of physical inactivity on associations between single nucleotide polymorphisms and genetic predisposition to childhood obesity
}}

{{PMID Auto
|PMID=22355368
|Title=Longitudinal Replication Studies of GWAS Risk SNPs Influencing Body Mass Index over the Course of Childhood and Adulthood
|OA=1
}}

{{PMID Auto
|PMID=19474294
|Title=Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.
|OA=1
}}

{{PMID Auto
|PMID=19478790
|Title=The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6499640
|overall_frequency_n=72
|overall_frequency_d=128
|overall_frequency=0.5625
|n_genomes=44
|n_genomes_annotated=0
|n_haplomes=64
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23251365
|Title=Genetic Variants in the Fat and Obesity Associated (FTO) Gene and Risk of Alzheimer's Disease
|OA=1
}}

{{PMID Auto
|PMID=24911064
|Title=Association of FTO Polymorphisms with Obesity and Metabolic Parameters in Han Chinese Adolescents
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}