{{Rsnum
|rsid=650108
|Gene=MMP3
|Chromosome=11
|position=102838056
|Orientation=plus
|GMAF=0.4118
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MMP3
}}[[rs650108]] is a SNP in the matrix metallopeptidase 3 [[MMP3]] gene on ch 11.

{{PMID|19042922}} A relatively small study (~100 patients) found associations between risk for [[Achilles tendinopathy]] and SNPs in the [[MMP3]] gene. For [[rs650108]], the (A;A) genotype had an odds ratio of 4.9 (CI: 1.0 to 24.1, p = 0.043).

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 4.6 | 36.9 | 58.5
| HCB | 37.8 | 46.7 | 15.6
| JPT | 37.8 | 46.7 | 15.6
| YRI | 9.5 | 44.4 | 46.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 37.8 | 46.7 | 15.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=19762026
|Title=Haplotypes and 5A/6A polymorphism of the matrix metalloproteinase-3 gene in coronary disease: Case-control study and a meta-analysis
}}

{{PharmGKB
|RSID=rs650108
|Name_s=
|Gene_s=MMP3
|Feature=
|Evidence=PubMed ID:20031604
|Annotation=In a GWAS performed on 778 healthy Amish adults, this SNP was significantly associated with levels of circulating MMP1. Phenotype: associated with circulating MMP1 levels. Study size:778. Study population/ethnicity: healthy Amish adults. Significance metric(s): P value: GC content -corrected p = 1.06 x 10 (-20). Type of association: CO; GN.
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA165111637
}}

{{PMID Auto
|PMID=21134112
|Title=Genetic polymorphisms of matrix metalloproteinase 3 in primary sclerosing cholangitis
|OA=1
}}

{{PMID Auto
|PMID=19318431
|Title=No association between matrix metalloproteinase-1 or matrix metalloproteinase-3 polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.
|OA=1
}}

{{PMID Auto
|PMID=19435861
|Title=No association between matrix metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and endometrial cancer risk.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs650108
|overall_frequency_n=47
|overall_frequency_d=128
|overall_frequency=0.367188
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22671570
|Title=MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}