{{Rsnum
|rsid=6505162
|Gene=CCDC55
|Chromosome=17
|position=30117165
|Orientation=plus
|GMAF=0.4885
|Gene_s=NSRP1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 30.4 | 58.0 | 11.6
| HCB | 5.1 | 22.6 | 72.3
| JPT | 5.3 | 32.7 | 61.9
| YRI | 62.3 | 34.2 | 3.4
| ASW | 54.4 | 38.6 | 7.0
| CHB | 5.1 | 22.6 | 72.3
| CHD | 1.8 | 30.3 | 67.9
| GIH | 22.8 | 43.6 | 33.7
| LWK | 57.4 | 35.2 | 7.4
| MEX | 12.1 | 51.7 | 36.2
| MKK | 65.8 | 30.9 | 3.3
| TSI | 17.6 | 51.0 | 31.4
| HapMapRevision=28
}}[[rs6505162]] is a SNP located in the pre-miRNA region of mir423. The major allele is [[rs6505162]](C).

A study of 346 Caucasians with [[esophageal cancer]] found that compared with the homozygous wild-type genotype of rs6505162, individuals with the heterozygous and homozygous variant genotype had a significantly reduced esophageal cancer risk with odds ratios of 0.58 (CI: 0.41-0.82) and 0.43 (CI: 0.27-0.68), respectively. After stratifying by gender, smoking, and age, the authors discovered that the protective effect was significant only for individuals under 64 years of age, regardless of sex or whether they smoked. Other unfavorable genotypes (ie SNPs) were also identified that were not as significant as [[rs6505162]], and the overall risk of [[esophageal cancer]] increased with increasing numbers of unfavorable SNPs.{{doi|10.1158/1940-6207.CAPR-08-0135}} {{PMID|19138993|OA=1
}}

{{snp near feature
| rsid = 6505162
| type = microRNA
| ACC=MI0001445
| ID=hsa-mir-423
| offset=-39
}}

discussed in [http://precedings.nature.com/documents/2127/version/1 nature]

{{PMID Auto
|PMID=19950226
|Title=SNPs in miRNA binding sites and miRNA genes as breast/ovarian cancer risk modifiers in Jewish high risk women
}}

{{PMID Auto
|PMID=22028396
|Title=Genetic polymorphisms in pre-microRNA genes as prognostic markers of colorectal cancer
|OA=1
}}

{{PMID Auto
|PMID=22593246
|Title=A Genetic Variant Located in miR-423 is Associated with Reduced Breast Cancer Risk
}}

{{PMID Auto
|PMID=18521189
|Title=Genetic variants of miRNA sequences and non-small cell lung cancer survival.
|OA=1
}}

{{PMID Auto
|PMID=19047128
|Title=Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.
|OA=1
}}

{{PMID Auto
|PMID=19458495
|Title=Comprehensive analysis of the impact of SNPs and CNVs on human microRNAs and their regulatory genes.
|OA=1
}}

{{PMID Auto
|PMID=22818121
|Title=The prognostic impact of microRNA sequence polymorphisms on the recurrence of patients with completely resected non-small cell lung cancer
}}

{{PMID Auto
|PMID=24205249
|Title=MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma
|OA=1
}}

{{PMID Auto
|PMID=24413317
|Title=MicroRNA sequence polymorphisms and the risk of different types of cancer
}}

{{PMID Auto
|PMID=24854593
|Title=Identification of miR-423 and miR-499 Polymorphisms on Affecting the Risk of Hepatocellular Carcinoma in a Large-Scale Population
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}