{{Rsnum
|rsid=650985
|Gene=GSTM4
|Chromosome=1
|position=109658958
|Orientation=minus
|GMAF=0.02388
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=GSTM4
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 88.4 | 9.8 | 1.8
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 99.3 | 0.7 | 0.0
| ASW | 96.5 | 3.5 | 0.0
| CHB | 100.0 | 0.0 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 94.1 | 5.9 | 0.0
| LWK | 98.2 | 1.8 | 0.0
| MEX | 94.8 | 5.2 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 92.2 | 7.8 | 0.0
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs650985
|Name_s=GSTM4: intron 6 2517T>C
|Gene_s=GSTM2, GSTM4
|Feature=
|Evidence=PubMed ID:12140136
|Annotation=Risk or phenotype-associated allele: rs650985 T allele Phenotype: The 2517 T allele of rs650985 in GSTM4 was shown to be associated with an increased risk of developing lung cancer; 23 out of 156 healthy controls versus only 12 out of 163 individuals with lung cancer carried the C allele. Study size: 219. Study population/ethnicity: Lung cancer cases (n = 163) and controls (n = 156) from Merseyside, England. Significance metric(s): OR= 2.23, p = 0.026. Type of association: CO; GN
|Drugs=
|Drug Classes=
|Diseases=Adenocarcinoma; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Lung Neoplasms; Neoplasms, Squamous Cell
|Curation Level=Curated
|PharmGKB Accession ID=PA165110433
}}

{{PMID Auto
|PMID=17601350
|Title=A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
|OA=1
}}

{{PMID Auto
|PMID=19151192
|Title=Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs650985
|overall_frequency_n=10283
|overall_frequency_d=10758
|overall_frequency=0.955847
|n_genomes=55
|n_genomes_annotated=0
|n_haplomes=108
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}