{{Rsnum
|rsid=652785
|Gene=C8A
|Chromosome=1
|position=56875054
|Orientation=minus
|ReferenceAllele=C
|MissenseAllele=A
|GMAF=0.3278
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=C8A
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 41.6 | 44.2 | 14.2
| HCB | 39.4 | 40.1 | 20.4
| JPT | 38.9 | 48.7 | 12.4
| YRI | 68.7 | 27.9 | 3.4
| ASW | 56.1 | 42.1 | 1.8
| CHB | 39.4 | 40.1 | 20.4
| CHD | 33.3 | 50.0 | 16.7
| GIH | 27.7 | 55.4 | 16.8
| LWK | 68.2 | 30.9 | 0.9
| MEX | 53.4 | 44.8 | 1.7
| MKK | 47.4 | 48.1 | 4.5
| TSI | 39.2 | 52.0 | 8.8
| HapMapRevision=28
}}{{Venter SNP
|rsid=652785
|allele=A
|frequency=0.383
|uid=1103675100292
|type=homozygous_SNP
|hugo=C8A
|ensembl gene=ENSG00000157131
|ensembl transcript=ENST00000361249
|sift=TOLERATED
|disease=Defects in C8A are a cause of complement C8 deficiency type I (MIM:120950). Patients with deficiency of C8 suffer from recurrent bacterial infections, predominantly from Neisseria meningitidis.
}}

{{PMID|15986317|OA=1
}} Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.

{{PMID|20029952|OA=1
}} Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study.

{{GET Evidence
|gene=C8A
|aa_change=Gln93Lys
|aa_change_short=Q93K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs652785
|overall_frequency_n=3402
|overall_frequency_d=10758
|overall_frequency=0.31623
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=39
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.012
|nblosum100=-2
|autoscore=0
|webscore=N
}}

{{ClinVar
|ALT=A
|CHROM=1
|CLNACC=RCV000018567.1
|CLNALLE=1
|CLNDBN=COMPLEMENT COMPONENT 8, ALPHA SUBUNIT, A/B POLYMORPHISM
|CLNHGVS=NC_000001.11:g.56875054C>A
|CLNORIGIN=1
|CLNSIG=2
|CLNSRC=ClinVar; OMIM Allelic Variant
|CLNSRCID=NM_000562.2:c.277C>A; 120950.0001
|Disease=COMPLEMENT COMPONENT 8
|FwdALT=T
|FwdREF=G
|GENEINFO=C8A:731
|GENE_ID=731
|GENE_NAME=C8A
|REF=C
|RSPOS=56875054
|Reversed=1
|SAO=0
|SSR=0
|Tags=RV;PM;PMC;S3D;SLO;NSM;REF;ASP;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3
|VC=SNV
|VP=0x050328000a0515051f000101
|WGT=1
|dbSNPBuildID=83
|rsid=652785
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}