{{Rsnum
|rsid=6539137
|Gene=TXNRD1
|Chromosome=12
|position=104313402
|Orientation=plus
|GMAF=0.0528
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=TXNRD1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 3.3 | 21.7 | 75.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|18996185}} [[rs6539137]] is one of several [[TXNRD1]] SNPs significantly associated with familial amyotrophic lateral sclerosis (FALS) but not sporadic amyotrophic lateral sclerosis ([[ALS]]). The risk allele, [[rs6539137]](A), is also associated with an earlier age of onset by 8 years, and the shift was more significant in males (in fact, insignificant in females).

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}