{{Rsnum
|rsid=6548238
|Chromosome=2
|position=634905
|Orientation=plus
|GMAF=0.1281
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 73.6 | 22.7 | 3.6
| HCB | 85.7 | 14.3 | 0.0
| JPT | 78.9 | 12.8 | 8.3
| YRI | 78.3 | 21.7 | 0.0
| ASW | 71.9 | 24.6 | 3.5
| CHB | 85.7 | 14.3 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 77.8 | 21.2 | 1.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 78.9 | 15.8 | 5.3
| MKK | 0.0 | 0.0 | 0.0
| TSI | 60.6 | 35.4 | 4.0
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19079261
|Trait=Body mass index
|Title=Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
|RiskAllele=C
|Pval=1E-18
|OR=0.26
|ORtxt=[0.19-0.34] kg/m2 increase
|OA=1
}}

{{PMID Auto
|PMID=19851340
|Title=Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population
}}

{{PharmGKB
|RSID=rs6548238
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079261; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. (Initial Sample Size: 32,387 individuals; Replication Sample Size: 59,092 individuals); (Region: 2p25.3; Reported Gene(s): TMEM18; Risk Allele: rs6548238-C); (p-value= 0.000000000000000001).This variant is associated with Body mass index.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740185
}}

{{omim
|desc=TRANSMEMBRANE PROTEIN 18; TMEM18
|id=613220
|rsnum=6548238
}}

{{PMID Auto
|PMID=20386550
|Title=Genes and lifestyle factors in obesity: results from 12 462 subjects from MONICA/KORA
|OA=1
}}
{{PMID Auto
|PMID=20380707
|Title=The obesity gene, TMEM18, is of ancient origin, found in majority of neuronal cells in all major brain regions and associated with obesity in severely obese children
|OA=1
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=22083549
|Title=Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty
}}

{{PMID Auto
|PMID=19164386
|Title=Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.
|OA=1
}}

{{PMID Auto
|PMID=19526209
|Title=Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
|OA=1
}}

{{PMID Auto
|PMID=19553259
|Title=Common body mass index-associated variants confer risk of extreme obesity.
|OA=1
}}

{{PMID Auto
|PMID=19910938
|Title=Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.
}}

{{PMID Auto
|PMID=20127379
|Title=From monogenic to polygenic obesity: recent advances.
|OA=1
}}

{{PMID Auto
|PMID=20520848
|Title=Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth.
|OA=1
}}

{{PMID Auto
|PMID=20628085
|Title=First investigation of two obesity-related loci (TMEM18, FTO) concerning their association with educational level as well as income: the MONICA/KORA study.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=20725061
|Title=MC4R variant is associated with BMI but not response to resistance training in young females.
}}

{{PMID Auto
|PMID=20824172
|Title=Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
|OA=1
}}

{{PMID Auto
|PMID=21283731
|Title=FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
|OA=1
}}

{{PMID Auto
|PMID=21593506
|Title=Maternal and offspring adiposity-related genetic variants and gestational weight gain.
|OA=1
}}

{{PMID Auto
|PMID=21952719
|Title=Association of TMEM18 variants with BMI and waist circumference in children and correlation of mRNA expression in the PFC with body weight in rats.
|OA=1
}}

{{PMID Auto
|PMID=22179955
|Title=Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program.
|OA=1
}}

{{PMID Auto
|PMID=22466342
|Title=beta2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6548238
|overall_frequency_n=115
|overall_frequency_d=126
|overall_frequency=0.912698
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=99
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

[[Obesity: Preliminary Research]]

[[Measures of Obesity]]

{{PMID Auto
|PMID=23311614
|Title=Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
|OA=1
}}

{{PMID Auto
|PMID=23775818
|Title=Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study.
}}

{{PMID Auto
|PMID=24762112
|Title=Increased body mass index, elevated C-reactive protein, and short telomere length
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}