{{Rsnum
|rsid=6564851
|Chromosome=16
|position=81230992
|Orientation=plus
|GMAF=0.4316
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 31.5 | 49.5 | 18.9
| HCB | 66.9 | 30.9 | 2.2
| JPT | 63.4 | 33.9 | 2.7
| YRI | 10.4 | 44.4 | 45.1
| ASW | 21.1 | 45.6 | 33.3
| CHB | 66.9 | 30.9 | 2.2
| CHD | 64.8 | 31.5 | 3.7
| GIH | 23.0 | 43.0 | 34.0
| LWK | 13.2 | 56.6 | 30.2
| MEX | 38.6 | 49.1 | 12.3
| MKK | 13.5 | 51.0 | 35.5
| TSI | 11.9 | 58.4 | 29.7
| HapMapRevision=28
}}{{PMID|19185284|OA=1
}} [[rs6564851]](G) associated with higher beta-carotene (p = 1.6 x 10(-24)) and alpha-carotene (p = 0.0001) levels and lower lycopene (0.003), zeaxanthin (p = 1.3 x 10(-5)), and lutein (p = 7.3 x 10(-15)) levels, with effect sizes ranging from 0.10-0.28 SDs per allele.

Note that low plasma levels of carotenoids and tocopherols are associated with increased risk of chronic disease and disability, yet dietary intake of these lipid-soluble antioxidant vitamins is only poorly correlated with plasma levels, leading to the hypothesis that it isn't what you eat, it's your SNPs that regulate your carotenoid levels.{{PMID|19185284|OA=1
}}

This is one of the SNPs reported by [[NutraHacker SNPs|NutraHacker]].

{{omim
|desc=HYPERCAROTENEMIA AND VITAMIN A DEFICIENCY, AUTOSOMAL DOMINANT
|id=115300
|rsnum=6564851
}}

{{PharmGKB
|RSID=rs6564851
|Name_s=
|Gene_s=BCMO1
|Feature=
|Evidence=PubMed ID:19185284; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study. (Initial Sample Size: 1,191 individuals; Replication Sample Size: 2,751 individuals); (Region: 16q23.2; Reported Gene(s): BCMO1; Risk Allele: rs6564851-G); (p-value= 2E-24).This variant is associated with Plasma carotenoid and tocopherol levels.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740024
}}

{{PMID Auto
|PMID=19662379
|Title=Circulating beta-carotene levels and type 2 diabetes-cause or effect?
|OA=1
}}

{{PMID Auto
|PMID=20616999
|Title=Usefulness of Mendelian randomization in observational epidemiology.
|OA=1
}}

{{PMID Auto
|PMID=22113863
|Title=Single nucleotide polymorphisms upstream from the beta-carotene 15,15'-monoxygenase gene influence provitamin A conversion efficiency in female volunteers.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6564851
|overall_frequency_n=58
|overall_frequency_d=128
|overall_frequency=0.453125
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=53
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23468552
|Title=Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}