{{Rsnum
|rsid=657152
|Gene=ABO
|Chromosome=9
|position=133263862
|Orientation=plus
|GMAF=0.3842
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Gene_s=ABO
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 38.1 | 48.7 | 13.3
| HCB | 42.6 | 42.6 | 14.7
| JPT | 32.7 | 54.0 | 13.3
| YRI | 32.4 | 49.7 | 17.9
| ASW | 29.1 | 56.4 | 14.5
| CHB | 42.6 | 42.6 | 14.7
| CHD | 46.3 | 45.4 | 8.3
| GIH | 33.7 | 45.5 | 20.8
| LWK | 24.8 | 59.6 | 15.6
| MEX | 63.2 | 26.3 | 10.5
| MKK | 33.1 | 50.3 | 16.6
| TSI | 38.6 | 40.6 | 20.8
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18940312
|Trait=Plasma levels of liver enzymes
|Title=Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes
|RiskAllele=T
|Pval=2E-30
|OR=0.05
|ORtxt=[0.039-0.055] U/L decrease
|OA=1
}}

The T allele of this SNP is associated with higher risk of [[pancreatic cancer]]. {{PMID|19648918|OA=1
}}

{{omim
|desc=ALKALINE PHOSPHATASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS 1
|id=171720
|rsnum=657152
}}

{{PharmGKB
|RSID=rs657152
|Name_s=
|Gene_s=ABO
|Feature=
|Evidence=PubMed ID:18940312; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. (Initial Sample Size: 7,751 European white individuals; Replication Sample Size: 4,704 European white and Indian Asian individua); (Region: 9p34.2; Reported Gene(s): ABO; Risk Allele: rs657152-T); (p-value= 2E-30).This variant is associated with Plasma levels of liver enzymes.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740809
}}

{{PMID Auto
|PMID=20529992
|Title=Genetic Regulation of Serum Phytosterol Levels and Risk of Coronary Artery Disease
}}

{{PMID|18514160|OA=1
}} Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.

{{PMID|18604267|OA=1
}} Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.

{{PMID|19474294|OA=1
}} Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

{{PMID|19729612|OA=1
}} Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.

{{PMID|21534939}} Genetic variants associated with Von Willebrand factor levels in healthy men and women identified using the HumanCVD BeadChip.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs657152
|overall_frequency_n=48
|overall_frequency_d=128
|overall_frequency=0.375
|n_genomes=33
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23408906
  |Trait=Thyroid hormone levels
  |Title=A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
  |RiskAllele=A
  |Pval=4E-10
  |OR=.06
  |ORtxt=[0.04-0.076] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=23707316
|Title=High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis
}}

{{PMID Auto
|PMID=23816557
|Title=Re-evaluation of ABO gene polymorphisms detected in a genome-wide association study and risk of pancreatic ductal adenocarcinoma in a Chinese population.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}