{{Rsnum
|rsid=6581612
|Chromosome=12
|position=65140844
|Orientation=plus
|GMAF=0.2213
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 52.3 | 45.0 | 2.7
| HCB | 98.5 | 1.5 | 0.0
| JPT | 99.1 | 0.9 | 0.0
| YRI | 40.8 | 49.3 | 9.9
| ASW | 42.9 | 48.2 | 8.9
| CHB | 98.5 | 1.5 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 64.3 | 33.7 | 2.0
| LWK | 35.8 | 50.9 | 13.2
| MEX | 65.5 | 29.1 | 5.5
| MKK | 62.7 | 30.1 | 7.2
| TSI | 67.6 | 29.4 | 2.9
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs6581612
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19926868
|Annotation=In GWAS of two Asthma family study cohorts, this SNP demonstrated replicated association with FVC(forced vital capacity), a measurement of lung function. Risk or phenotype-associated allele: C . Phenotype: higher value for FVC. Study size/population/ethnicity: 403 parent -child trios from the Childhood Asthma Management Program (CAMP) and 583 parent-child trios from the Genetics of Asthma in Costa Rica study. Significance metric(s): combined p = 0.003. Type of association: GN
|Drugs=
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA165111747
}}

{{PMID Auto GWAS
|PMID=22504421
|Trait=None
|Title=Common variants at 12q14 and 12q24 are associated with hippocampal volume.
|RiskAllele=C
|Pval=7E-11
|OR=63.3000
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6581612
|overall_frequency_n=93
|overall_frequency_d=128
|overall_frequency=0.726562
|n_genomes=50
|n_genomes_annotated=0
|n_haplomes=81
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23315860
|Title=Genetic variations in the Wnt signaling pathway affect lung function in asthma patients
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}