{{Rsnum
|rsid=6583817
|Gene=IDE
|Chromosome=10
|position=94247247
|Orientation=plus
|GMAF=0.1873
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 75.2 | 22.1 | 2.7
| HCB | 67.2 | 29.9 | 2.9
| JPT | 55.8 | 33.6 | 10.6
| YRI | 42.9 | 47.6 | 9.5
| ASW | 35.1 | 57.9 | 7.0
| CHB | 67.2 | 29.9 | 2.9
| CHD | 68.8 | 30.3 | 0.9
| GIH | 66.3 | 30.7 | 3.0
| LWK | 67.9 | 28.4 | 3.7
| MEX | 58.6 | 32.8 | 8.6
| MKK | 72.9 | 24.5 | 2.6
| TSI | 81.4 | 17.6 | 1.0
| HapMapRevision=28
}}

[[rs6583817]], also known as v311, is a SNP within an intron of the [[IDE]] gene, which encodes the insulin-degrading enzyme.

Late onset [[Alzheimer's disease]] is a neurodegenerative condition in which the brain develops large numbers of extracellular senile plaques composed primarily of aggregated amyloid-B proteins as well as intraneuronal neurofibrillary tangles composed mainly of aggregated tau protein.{{PMID|15450169}} One notable function of insulin-degrading enzyme is its ability to degrade amyloid-B and therefore to influence the amount of amyloid-B found in the brain.{{PMID|12634421|OA=1
}}

A study of ~3,000 patients (and an equal number of matched controls) found that carriers of one or two minor alleles, i.e. [[rs6583817]](T), had ~2x higher levels of insulin-degrading enzyme (p < 10e-8), lower levels of amyloid-B, and a (slightly) lower risk of [[Alzheimer's disease]], with an odds ratio of around 0.80 (p < 0.03), depending on the population studied. [[rs6583817]] is thought to be a functional variant based on in vitro studies.{{PMID|20098734|OA=1
}}

While [[rs6583817]] may be a functional variant, it is nearly perfectly linked to nearby SNP [[rs7910977]], which is more commonly found on Illumina microarrays. The [[rs7910977]](T) allele was also shown to correlate with decreased amyloid-B levels (presumably due to linkage with [[rs6583817]]), and it can be used to predict the presence of a [[rs6583817]](T) allele.{{PMID|20098734|OA=1
}}

{{PMID Auto
|PMID=21731745
|Title=Multiple Insulin Degrading Enzyme Variants Alter In Vitro Reporter Gene Expression
|OA=1
}}

{{PMID Auto
|PMID=23597493
|Title=IDE (rs6583817) polymorphism and type 2 diabetes differentially modify executive function in older adults
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}