{{Rsnum
|rsid=6586282
|Gene=CBS
|Chromosome=21
|position=43058387
|Orientation=plus
|GMAF=0.1419
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CBS
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 66.4 | 31.0 | 2.7
| HCB | 98.5 | 1.5 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 60.5 | 32.0 | 7.5
| ASW | 49.1 | 45.6 | 5.3
| CHB | 98.5 | 1.5 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 77.0 | 20.0 | 3.0
| LWK | 58.2 | 37.3 | 4.5
| MEX | 75.4 | 22.8 | 1.8
| MKK | 63.5 | 31.4 | 5.1
| TSI | 64.7 | 32.4 | 2.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=20031578
|Trait=Plasma homocysteine
|Title=Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population: A Genome-Wide Evaluation of 13 974 Participants in the Women's Genome Health Study
|RiskAllele=
|Pval=3E-10
|OR=0.03
|ORtxt=[NR] unit decrease in log(homocysteine)
|OA=1
}}

{{PMID Auto
|PMID=18818748
|Title=Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants.
|OA=1
}}

{{PMID Auto
|PMID=19303062
|Title=Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.
|OA=1
}}

{{PMID Auto
|PMID=19525478
|Title=Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6586282
|overall_frequency_n=22
|overall_frequency_d=126
|overall_frequency=0.174603
|n_genomes=15
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23720494
  |Trait=Blood trace element (Se levels)
  |Title=Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
  |RiskAllele=
  |Pval=5E-6
  |OR=.12
  |ORtxt=[0.068-0.166] unit increase
  }}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}