{{Rsnum
|rsid=660895
|Chromosome=6
|position=32609603
|Orientation=plus
|GMAF=0.2089
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 52.2 | 39.8 | 8.0
| HCB | 63.5 | 32.8 | 3.6
| JPT | 50.4 | 39.8 | 9.7
| YRI | 80.3 | 19.0 | 0.7
| ASW | 66.7 | 29.8 | 3.5
| CHB | 63.5 | 32.8 | 3.6
| CHD | 59.6 | 36.7 | 3.7
| GIH | 76.2 | 20.8 | 3.0
| LWK | 85.5 | 14.5 | 0.0
| MEX | 44.8 | 44.8 | 10.3
| MKK | 70.5 | 27.6 | 1.9
| TSI | 76.5 | 21.6 | 2.0
| HapMapRevision=28
}}
This SNP, along with SNPs [[rs6910071]] and [[rs3817964]], is a tag SNP for the HLA-DRB1*0401 allele.

The HLA-DRB1*0401 allele has been associated with higher risk for [[rheumatoid arthritis]], and in particular, rheumatoid vasculitis. The association is seen particularly for individuals carrying two copies of, i.e. homozygous for, the allele. The reported odds ratio for [[rs660895(G;G)]] homozygotes is 6.2 (CI: 1.01 - 37.9).
{{PMID|15529352}}

The risk for [[rheumatoid arthritis]] may be higher for individuals carrying one copy (one "dose") of the HLA-DRB1*0401 allele, if they also carry a different HLA-DRB1 risk allele. In particular, *0401/*0404 individuals are reported to have an odds ratio for rheumatoid vasculitis of 4.1 (CI: 1.1 - 16.2), and *0401/*0101 individuals have an odds ratio of 4.0 (CI: 1.4 - 11.6). {{PMID|15529352}}

*(A;A) is 0 dose of HLA-DRB1*0401
*(A;G) is 1 dose of HLA-DRB1*0401

{{PMID Auto GWAS
|PMID=17804836
|Trait=Rheumatoid arthritis
|Title=TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study
|RiskAllele=
|Pval=1E-108
|OR=3.62
|ORtxt=[NR]
|OA=1
}}

{{PMID|24270849|OA=1
}} [[rs660895]] was found to be associated with [[rheumatoid arthritis]] based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.
{{PMID Auto GWAS
|PMID=22197929
|Trait=None
|Title=A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
|RiskAllele=G
|Pval=4E-20
|OR=1.3400
|ORtxt=None
}}

{{PMID Auto
|PMID=22355377
|Title=Caucasian and asian specific rheumatoid arthritis risk Loci reveal limited replication and apparent allelic heterogeneity in north indians
|OA=1
}}

{{PMID Auto
|PMID=15747258
|Title=A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms.
|OA=1
}}

{{PMID Auto
|PMID=18438406
|Title=Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=19116921
|Title=Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
|OA=1
}}

{{PMID Auto
|PMID=19143813
|Title=Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A.
|OA=1
}}

{{PMID Auto
|PMID=19143815
|Title=MHC fine mapping of human type 1 diabetes using the T1DGC data.
|OA=1
}}

{{PMID Auto
|PMID=19458352
|Title=Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
|OA=1
}}

{{PMID Auto
|PMID=20017995
|Title=A principal-components-based clustering method to identify multiple variants associated with rheumatoid arthritis and arthritis-related autoantibodies.
|OA=1
}}

{{PMID Auto
|PMID=20018015
|Title=Elastic-net regularization approaches for genome-wide association studies of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20018024
|Title=On the association between rheumatoid arthritis and classical HLA class I and class II alleles predicted from single-nucleotide polymorphism data.
|OA=1
}}

{{PMID Auto
|PMID=20018025
|Title=Genome-wide analysis of haplotype interaction for the data from the North American Rheumatoid Arthritis Consortium.
|OA=1
}}

{{PMID Auto
|PMID=20018053
|Title=A genome-wide association scan for rheumatoid arthritis data by Hotelling's T2 tests.
|OA=1
}}

{{PMID Auto
|PMID=20018057
|Title=Detecting single-nucleotide polymorphism by single-nucleotide polymorphism interactions in rheumatoid arthritis using a two-step approach with machine learning and a Bayesian threshold least absolute shrinkage and selection operator (LASSO) model.
|OA=1
}}

{{PMID Auto
|PMID=20018067
|Title=A two-stage search strategy for detecting multiple loci associated with rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20018071
|Title=Allelic based gene-gene interactions in rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20018077
|Title=Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=20018080
|Title=Effects of covariates and interactions on a genome-wide association analysis of rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20018081
|Title=Assessment of gene-covariate interactions by incorporating covariates into association mapping.
|OA=1
}}

{{PMID Auto
|PMID=20369022
|Title=Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
|OA=1
}}

{{PMID Auto
|PMID=20797713
|Title=Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs660895
|overall_frequency_n=23
|overall_frequency_d=124
|overall_frequency=0.185484
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23961418
|Title=Association of the HLA locus and TNF with type I autoimmune hepatitis susceptibility in New Zealand Caucasians
|OA=1
}}

{{PMID Auto
|PMID=22807207
|Title=Association between Parkinson's disease and the HLA-DRB1 locus.
}}

{{PMID Auto
|PMID=23223422
|Title=Identification of the NF-kappaB activating protein-like locus as a risk locus for rheumatoid arthritis.
|OA=1
}}

{{PMID Auto
|PMID=23678157
|Title=Integrative analyses for functional mechanisms underlying associations for rheumatoid arthritis.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}