{{Rsnum
|rsid=662
|Gene=PON1
|Chromosome=7
|position=95308134
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.4835
|Gene_s=PON1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 43.4 | 46.9 | 9.7
| HCB | 16.1 | 48.9 | 35.0
| JPT | 7.1 | 47.8 | 45.1
| YRI | 3.4 | 37.4 | 59.2
| ASW | 17.5 | 40.4 | 42.1
| CHB | 16.1 | 48.9 | 35.0
| CHD | 12.0 | 47.2 | 40.7
| GIH | 44.6 | 39.6 | 15.8
| LWK | 7.3 | 26.4 | 66.4
| MEX | 24.1 | 51.7 | 24.1
| MKK | 12.2 | 46.8 | 41.0
| TSI | 57.8 | 36.3 | 5.9
| HapMapRevision=28
}}
[[rs662]], also known as Q192R, is a SNP in the [[PON1]] gene.  It codes for amino acid 192 of the paraoxonase (PON) protein.  Variants of this SNP affect PON catalytic efficiency and are correlated with [[Heart disease]] and trait-anxiety scores.  The normal form, [[rs662]](A), encodes a glutamine (Q), while the variant, [[rs662]](G)), encodes an arginine (R). {{PMID|8675673|OA=1
}}. While some populations show an association between this SNP and [[Heart disease]], not all do.

Perhaps the most striking finding was reported in Japanese patients with non-insulin dependent diabetes mellitus (NIDDM). NIDDM patients with either one or two [[rs662]](G) alleles had a 9 fold higher risk of coronary heart disease compared with [[rs662]](A;A) NIDDM patients. {{PMID|9215303}}

[http://www.theheart.org/article/848219.do table] of odds for cardiovascular disease outcomes

{{PMID|18708400|OA=1
}} 274 ovarian epithelial carcinoma cases and 452 controls. [[rs662]] odds ratio 0.65 (CI: 0.44-0.95; p for allele-dose effect = 0.03) for [[ovarian cancer]] for women carrying the [[rs662]](A) allele compared with women with the (G;G) genotype

{{PMID|19263529|OA=1
}} [[rs1799864]](G), [[rs3025058]](A) and [[rs662]] were associated with increased risk, and [[rs1800775]](A) with reduced risk of recurrent [[venous thromboembolism]]

{{PMID|15060281)}} In a study of 461 participants in the HERITAGE cohort (172 African-American, 289 Caucasian), the combination of [[rs662]] with [[rs854560]] was found to significantly contribute to trait-anxiety scores.  The high trait-anxiety group included "significantly more subjects homozygous to the Alzheimer's disease- predictive PON192 variant."  The authors also cite another paper, {{PMID|12525679}}, which found that this SNP affects PON's catalytic efficiency.  From the context, it appears that it is the "R" variant, or [[rs662]](G), which corresponds to the higher trait-anxiety scores and reduced catalytic efficiency, though this is less explicitly stated than one might hope.

{{PMID|19321847|OA=1
}} No association between [[rs662]] and amyotrophic lateral sclerosis was seen in this large meta-analysis.

{{omim
|desc=CORONARY ARTERY DISEASE, SUSCEPTIBILITY TO
|id=168820
|rsnum=662
|variant=0001
}}

{{PMID Auto
|PMID=19651761
|Title=The paraoxonase (PON1) Q192R polymorphism is not associated with poor health status or depression in the ELSA or INCHIANTI studies
|OA=1
}}
{{PMID Auto
|PMID=19357718
|Title=Genetic polymorphisms of paraoxonase-1 are associated with chronic kidney disease in Japanese women
}}
{{PMID Auto
|PMID=19778663
|Title=Paraoxonase variants relate to 10-year risk in coronary artery disease: impact of a high-density lipoprotein-bound antioxidant in secondary prevention
}}

{{PMID Auto
|PMID=20947215
|Title=Paraoxonase-1 polymorphisms in Alzheimer's disease, Parkinson's disease, and AD-PD spectrum diseases
|OA=1
}}
{{PMID Auto
|PMID=21122033
|Title=Leukoaraiosis is associated with genes regulating blood-brain barrier homeostasis in ischaemic stroke patients
}}
{{PMID Auto
|PMID=21223581
|Title=Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus
|OA=1
}}

{{PMID Auto
|PMID=20488557
|Title=Decreased serum arylesterase activity in autism spectrum disorders
}}

{{PMID Auto
|PMID=21567207
|Title=Tetra primer ARMS-PCR relates folate/homocysteine pathway genes and ACE gene polymorphism with coronary artery disease
}}

{{PMID Auto
|PMID=22133529
|Title=Paraoxonase 1 genetic polymorphisms and susceptibility to breast cancer: A meta-analysis
}}

{{PMID Auto
|PMID=22187169
|Title=A New PCR Method: One Primer Amplification of PCR-CTPP Products
}}

{{PMID Auto
|PMID=22206979
|Title=Genetic variants in antioxidant genes are associated with sperm DNA damage and risk of male infertility in a Chinese population
}}

{{PMID Auto
|PMID=22615820
|Title=Paraoxonase 1 Polymorphism and Prenatal Pesticide Exposure Associated with Adverse Cardiovascular Risk Profiles at School Age
|OA=1
}}

{{ClinVar
|rsid=662
|Reversed=1
|FwdREF=A
|FwdALT=G
|REF=T
|ALT=C
|RSPOS=94937446
|CHROM=7
|GMAF=0.484
|dbSNPBuildID=36
|SSR=0
|SAO=1
|VP=0x05037800000015051f110100
|GENEINFO=PON1:5444
|GENE_NAME=PON1
|GENE_ID=5444
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000007.13:g.94937446T>C
|CLNORIGIN=1
|CLNSIG=255
|Tags=RV;PM;TPA;PMC;S3D;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|CAF=0.4835; 0.5165
|CLNACC=RCV000014739.1; RCV000014740.1
|CLNDBN=Coronary artery disease, susceptibility to; Coronary artery spasm 2, susceptibility to
|CLNDSDB=MedGen
|CLNDSDBID=C1840169
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=168820.0001
|COMMON=1
|Disease=Coronary artery disease; Coronary artery spasm 2
}}

{{PMID Auto
|PMID=18034366
|Title=Lack of replication of genetic associations with human longevity.
}}

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{PMID Auto
|PMID=18203168
|Title=Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts.
|OA=1
}}

{{PMID Auto
|PMID=18282109
|Title=Adaptations to climate in candidate genes for common metabolic disorders.
|OA=1
}}

{{PMID Auto
|PMID=18513389
|Title=New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.
|OA=1
}}

{{PMID Auto
|PMID=18603647
|Title=Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
|OA=1
}}

{{PMID Auto
|PMID=18618303
|Title=A common haplotype within the PON1 promoter region is associated with sporadic ALS.
|OA=1
}}

{{PMID Auto
|PMID=18682580
|Title=Oxidative response gene polymorphisms and risk of adult brain tumors.
|OA=1
}}

{{PMID Auto
|PMID=18787196
|Title=Segment-specific genetic effects on carotid intima-media thickness: the Northern Manhattan study.
|OA=1
}}

{{PMID Auto
|PMID=18936436
|Title=Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
|OA=1
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19104460
|Title=Interaction between PON1 and population density in amyotrophic lateral sclerosis.
}}

{{PMID Auto
|PMID=19131662
|Title=A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
|OA=1
}}

{{PMID Auto
|PMID=19276285
|Title=Associations between single nucleotide polymorphisms in double-stranded DNA repair pathway genes and familial breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19587357
|Title=A systematic meta-analysis of genetic association studies for diabetic retinopathy.
|OA=1
}}

{{PMID Auto
|PMID=20031584
|Title=Genetics of atherothrombotic and lacunar stroke.
|OA=1
}}

{{PMID Auto
|PMID=20056567
|Title=Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes.
|OA=1
}}

{{PMID Auto
|PMID=20140262
|Title=Maternal and fetal genetic associations of PTGER3 and PON1 with preterm birth.
|OA=1
}}

{{PMID Auto
|PMID=20381198
|Title=Lack of association of PON polymorphisms with sporadic ALS in an Italian population.
}}

{{PMID Auto
|PMID=20616999
|Title=Usefulness of Mendelian randomization in observational epidemiology.
|OA=1
}}

{{PMID Auto
|PMID=20856122
|Title=Paraoxonase 1 polymorphisms and ischemic stroke risk: A systematic review and meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=21231776
|Title=C-reactive protein levels are associated with paraoxonase polymorphism L55M in patients undergoing cardiac SPECT imaging.
}}

{{PMID Auto
|PMID=21438666
|Title=Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.
}}

{{PMID Auto
|PMID=21543280
|Title=Relation between methylmercury exposure and plasma paraoxonase activity in inuit adults from Nunavik.
|OA=1
}}

{{PMID Auto
|PMID=21685174
|Title=Paraoxonase-1 Q192R polymorphism and antiplatelet effects of clopidogrel in patients undergoing elective coronary stent placement.
}}

{{PMID Auto
|PMID=22520065
|Title=Influence of the paraoxonase-1 Q192R genetic variant on clopidogrel responsiveness and recurrent cardiovascular events: a systematic review and meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=22976839
|Title=NQO1 rs1800566 (C609T), PON1 rs662 (Q192R), and PON1 rs854560 (L55M) polymorphisms segregate the risk of childhood acute leukemias according to age range distribution
}}

{{GET Evidence
|gene=PON1
|aa_change=Gln192Arg
|aa_change_short=Q192R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs662
|overall_frequency_n=4431
|overall_frequency_d=10758
|overall_frequency=0.41188
|n_genomes=40
|n_genomes_annotated=0
|n_haplomes=58
|n_articles=1
|n_articles_annotated=1
|qualityscore_in_silico=3
|qualitycomment_in_silico=Y
|in_omim=Y
|nblosum100=0
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23167629
|Title=Common genetic variants in the myeloperoxidase and paraoxonase genes and the related cancer risk: a review
}}

{{PMID Auto
|PMID=23391848
|Title=OLR1 , PON1 and MTHFR Gene Polymorphisms, Conventional Risk Factors and the Severity of Coronary Atherosclerosis in a Chinese Han Population
}}

{{PMID Auto
|PMID=23356507
|Title=Association between paraoxonase gene and stroke in the Han Chinese population
|OA=1
}}

{{PMID Auto
|PMID=23651475
|Title=Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study
|OA=1
}}

{{PMID Auto
|PMID=24206655
|Title=Association of a polymorphism in PON-1 gene with steroid-induced osteonecrosis of femoral head in Chinese Han population
}}

{{PMID Auto
|PMID=23903878
|Title=Prenatal methylmercury exposure and genetic predisposition to cognitive deficit at age 8 years
}}

{{PMID Auto
|PMID=24448003
|Title=Methylmercury exposure, PON1 gene variants and serum paraoxonase activity in Eastern James Bay Cree adults
}}

{{PMID Auto
|PMID=22877234
|Title=Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Meniere's disease in a Japanese population.
|OA=1
}}

{{PMID Auto
|PMID=22884547
|Title=Association analysis of PON polymorphisms in sporadic ALS in a Chinese population.
}}

{{PMID Auto
|PMID=23625196
|Title=The Q192R polymorphism of the paraoxonase 1 gene is a risk factor for coronary artery disease in Saudi subjects.
}}

{{PMID Auto
|PMID=24833785
|Title=Investigation of a PON1 gene polymorphism (rs662 polymorphism) as predictor of subclinical atherosclerosis in patients with rheumatoid arthritis
}}

{{PMID Auto
|PMID=24100645
|Title=Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy
}}

{{PMID Auto
|PMID=24903972
|Title=Genetic predisposition to calcific aortic stenosis and mitral annular calcification
}}

{{PMID Auto
|PMID=24918121
|Title=Association between PON1 rs662 polymorphism and coronary artery disease
}}

{{PMID Auto
|PMID=24965284
|Title=Synergistic Epistasis of Paraoxonase 1 (rs662 and rs85460) and Apolipoprotein E4 Genes in Pathogenesis of Alzheimer's Disease and Vascular Dementia
}}

{{PMID Auto
|PMID=24972570
|Title=PON1 Q192R polymorphism (rs662) is associated with childhood embryonal tumors
}}

{{PMID Auto
|PMID=24981930
|Title=Relationships between PON1 Q192R polymorphism and clinical outcome of antiplatelet treatment after percutaneous coronary intervention: a meta-analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}