{{Rsnum
|rsid=662799
|Gene=APOA5
|Chromosome=11
|position=116792991
|Orientation=plus
|GMAF=0.1524
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=APOA5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 96.9 | 3.1 | 0.0
| HCB | 51.1 | 44.4 | 4.4
| JPT | 46.5 | 48.8 | 4.7
| YRI | 74.6 | 23.8 | 1.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 51.1 | 44.4 | 4.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

[[rs662799]] is a SNP in the [[APOA5]] gene. The rarer [[rs662799]](C) allele has been associated in multiple reports (cited below) to be associated with higher triglyceride levels.

Independently of triglyceride levels, perhaps, a study based on 1,864 Italian patients <45 years old at the time of their first heart attack ([[myocardial infarction]]) concluded that this SNP is associated with higher risk for an early heart attack, with a per C allele odds ratio of 1.44 (CI: 1.23-1.69, p = 6.7 × 10(-5)).{{PMID|21130994}}

This SNP has also been reported to help prevent [http://www.medicalnewstoday.com/medicalnews.php?newsid=67543 weight gain from high fat diets].

{{PMID|17211608}} 1,073 men and 1,207 women participating in the Framingham Offspring Study  [[rs662799]] -1131T>C in modulates the effect of fat intake on BMI and [[obesity]] risk in both men and women. Individuals with at least one C allele gained significantly less weight on a high fat diet than those homozygous for the T allele.

{{PMID|18596051}} [[rs662799]] (-1131T>C) influences severe [[hypertriglyceridemia]]. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched controls

{{PMID Auto
|PMID=19732897
|Title=Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese
}}

{{PMID Auto
|PMID=20395964
|Title=Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins
}}
{{PMID Auto
|PMID=20429872
|Title=Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study
|OA=1
}}
{{PMID Auto
|PMID=20571505
|Title=A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese
|OA=1
}}
{{PMID Auto
|PMID=20883102
|Title=Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients
}}

{{PharmGKB
|RSID=rs662799
|Name_s=
|Gene_s=APOA5, ZNF259
|Feature=
|Evidence=PubMed ID:19802338
|Annotation=Phenotype: In a GWAS, this SNP was significantly associated with plasma concentrations of triglycerides. Study size:6382. Study population/ethnicity: Caucasian women. Significance metric(s): p = 2.9 x 10(-15). Type of association: CO; GN
|Drugs=
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA165111812
}}
{{PMID Auto
|PMID=21130994
|Title=Strong association of the APOA5-1131T&gt;C gene variant and early-onset acute myocardial infarction
}}

{{PMID Auto
|PMID=21375366
|Title=Impact of apolipoprotein A5 (APOA5) polymorphisms on serum triglyceride levels in schizophrenic patients under long-term atypical antipsychotic treatment
}}

{{PMID Auto
|PMID=16670016
|Title=Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene.
|OA=1
}}

{{PMID Auto
|PMID=17357073
|Title=Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
|OA=1
}}

{{PMID Auto
|PMID=17903299
|Title=A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=18078817
|Title=Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.
|OA=1
}}

{{PMID Auto
|PMID=18196181
|Title=Correction of population stratification in large multi-ethnic association studies.
|OA=1
}}

{{PMID Auto
|PMID=18441017
|Title=An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.
|OA=1
}}

{{PMID Auto
|PMID=18789138
|Title=The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides.
|OA=1
}}

{{PMID Auto
|PMID=19018513
|Title=The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.
}}

{{PMID Auto
|PMID=19041386
|Title=Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
|OA=1
}}

{{PMID Auto
|PMID=19056598
|Title=Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.
|OA=1
}}

{{PMID Auto
|PMID=19057464
|Title=Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.
|OA=1
}}

{{PMID Auto
|PMID=19148283
|Title=Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=19185284
|Title=Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19299407
|Title=Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.
|OA=1
}}

{{PMID Auto
|PMID=19435741
|Title=Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
|OA=1
}}

{{PMID Auto
|PMID=19656773
|Title=A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
|OA=1
}}

{{PMID Auto
|PMID=19787382
|Title=Introduction to the DISRUPT postprandial database: subjects, studies and methodologies.
|OA=1
}}

{{PMID Auto
|PMID=20406163
|Title=Fenofibrate and metabolic syndrome.
}}

{{PMID Auto
|PMID=20452521
|Title=Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.
|OA=1
}}

{{PMID Auto
|PMID=20570915
|Title=Genetic determinants of major blood lipids in Pakistanis compared with Europeans.
}}

{{PMID Auto
|PMID=20832063
|Title=Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.
}}

{{PMID Auto
|PMID=21054477
|Title=Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese.
}}

{{PMID Auto
|PMID=21324458
|Title=Association of gene variants with lipid levels in response to fenofibrate is influenced by metabolic syndrome status.
|OA=1
}}

{{PMID Auto
|PMID=21423763
|Title=Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels.
|OA=1
}}

{{PMID Auto
|PMID=21438666
|Title=Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.
}}

{{PMID Auto
|PMID=22387725
|Title=Rapid genotyping of APOA5 -1131T>C polymorphism using high resolution melting analysis with unlabeled probes.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs662799
|overall_frequency_n=115
|overall_frequency_d=128
|overall_frequency=0.898438
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=94
|n_articles=3
|n_articles_annotated=3
|in_pharmgkb=Y
|autoscore=1
|webscore=N
|summary_short=associated with the triglyceride levels and the risk of first heart attack 
}}

{{PMID Auto
|PMID=23150898
|Title=Evaluation of seven common lipid associated loci in a large Indian sib pair study
|OA=1
}}

[[Response to Diet and Exercise]]

{{PMID Auto
|PMID=23050023
|Title=Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals
|OA=1
}}

{{PMID Auto
|PMID=22517333
|Title=Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.
}}

{{PMID Auto
|PMID=22576629
|Title=Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome.
}}

{{PMID Auto
|PMID=22924697
|Title=Interactions between the apolipoprotein a1/c3/a5 haplotypes and alcohol consumption on serum lipid levels.
}}

{{PMID Auto
|PMID=23065249
|Title=Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke.
}}

{{PMID Auto
|PMID=23459084
|Title=Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}