{{Rsnum
|rsid=663048
|Gene=SEZ6L
|Chromosome=22
|position=26299111
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.2071
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=SEZ6L
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 67.3 | 28.3 | 4.4
| HCB | 92.0 | 7.3 | 0.7
| JPT | 87.6 | 12.4 | 0.0
| YRI | 39.5 | 42.9 | 17.7
| ASW | 45.6 | 43.9 | 10.5
| CHB | 92.0 | 7.3 | 0.7
| CHD | 90.7 | 8.3 | 0.9
| GIH | 84.2 | 13.9 | 2.0
| LWK | 50.0 | 41.8 | 8.2
| MEX | 75.9 | 22.4 | 1.7
| MKK | 46.8 | 46.8 | 6.4
| TSI | 52.9 | 43.1 | 3.9
| HapMapRevision=28
}}[[rs663048]] associated with [[lung cancer]]

The homozygotes for the variant allele had more than a 3-fold risk compared with the wild-type homozygotes [combined odds ratio (OR), 3.32; 95% confidence interval (95% CI), 1.81-7.21]. Heterozygotes also had a significantly elevated risk of lung cancer from the combined replication studies with an OR of 1.15 (95% CI, 1.04-1.59). The effect remained significant after adjusting for age, gender, and pack-years of tobacco smoke.007;67(17):8406-11]. {{PMID|17804757}}

{{Venter SNP
|rsid=663048
|allele=T
|frequency=0.225
|uid=1103691020349
|type=heterozygous_SNP
|hugo=SEZ6L
|ensembl gene=ENSG00000100095
|ensembl transcript=ENST00000248933
|sift=AFFECT FUNCTION
|disease=SEZ6L is located in a 22q region, which is frequently deleted in small cell lung carcinomas (SCLCs) and advanced non- small cell lung carcinomas.
}}

{{GET Evidence
|gene=SEZ6L
|aa_change=Met430Ile
|aa_change_short=M430I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs663048
|overall_frequency_n=2824
|overall_frequency_d=10758
|overall_frequency=0.262502
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=22
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.712
|nblosum100=-1
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}