{{Rsnum
|rsid=6675281
|Gene=DISC2
|Chromosome=1
|position=231818355
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.09275
|Gene_s=DISC1
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 70.3 | 27.9 | 1.8
| HCB | 100.0 | 0.0 | 0.0
| JPT | 100.0 | 0.0 | 0.0
| YRI | 70.1 | 25.2 | 4.8
| ASW | 80.7 | 17.5 | 1.8
| CHB | 100.0 | 0.0 | 0.0
| CHD | 99.1 | 0.9 | 0.0
| GIH | 96.0 | 4.0 | 0.0
| LWK | 67.3 | 27.3 | 5.5
| MEX | 87.9 | 12.1 | 0.0
| MKK | 82.7 | 17.3 | 0.0
| TSI | 80.4 | 17.6 | 2.0
| HapMapRevision=28
}}
linked to [[schizophrenia]]

{{Venter SNP
|rsid=6675281
|allele=T
|frequency=0.142
|uid=1103675362436
|type=heterozygous_SNP
|hugo=DISC1
|ensembl gene=ENSG00000162946
|ensembl transcript=ENST00000366638
|sift=
|disease=A chromosomal aberration involving DISC1 segregates with schizophrenia and related psychiatric disorders in a large Scottish family. Translocation t(1;11)(q42.1;q14.3).
}}

{{omim
|desc=DISRUPTED IN SCHIZOPHRENIA 1; DISC1
|id=605210
|rsnum=6675281
}}
{{PMID Auto
|PMID=19805229
|Title=DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
|OA=1
}}

{{PMID Auto
|PMID=20505556
|Title=Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations
}}

{{PMID Auto
|PMID=15386212
|Title=Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.
|OA=1
}}

{{PMID Auto
|PMID=19255581
|Title=Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies.
}}

{{PMID Auto
|PMID=19300510
|Title=The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.
|OA=1
}}

{{PMID Auto
|PMID=19414483
|Title=The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.
|OA=1
}}

{{PMID Auto
|PMID=20531374
|Title=Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.
}}

{{PMID Auto
|PMID=21878470
|Title=Effect of DISC1 on the P300 Waveform in Psychosis.
|OA=1
}}

{{GET Evidence
|gene=DISC1
|aa_change=Leu607Phe
|aa_change_short=L607F
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6675281
|overall_frequency_n=1660
|overall_frequency_d=10758
|overall_frequency=0.154304
|n_genomes=13
|n_genomes_annotated=0
|n_haplomes=15
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.98
|nblosum100=0
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23389941
|Title=DISC1 in adult ADHD patients: An association study in two European samples
}}

{{PMID Auto
|PMID=23140672
|Title=DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study
}}

{{ClinVar
|ALT=T
|CAF=0.9073; 0.09275
|CHROM=1
|CLNALLE=1
|CLNHGVS=NC_000001.11:g.231818355C>T
|CLNSIG=1
|COMMON=1
|FwdALT=T
|FwdREF=C
|GENEINFO=TSNAX-DISC1:100303453; DISC2:27184; DISC1:27185
|GENE_ID=100303453; 27184; 27185
|GENE_NAME=TSNAX-DISC1; DISC2; DISC1
|REF=C
|RSPOS=231818355
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;SLO;NSM;REF;SYN;U3;INT;ASP;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;OM
|VC=SNV
|VP=0x050168880b0515051f110100
|WGT=1
|dbSNPBuildID=116
|rsid=6675281
|CLNACC=RCV000084646.1
|CLNDBN=not provided
|Disease=not provided
|CLNORIGIN=0
|CLNSRC=ClinVar
|CLNSRCID=NM_001164545.1:c.1716C>T; NM_001164546.1:c.1634+47285C>T; NM_001164548.1:c.*5C>T; NM_018662.2:c.1819C>T; NR_002227.2:n.163G>A
}}

{{PMID Auto
|PMID=23602339
|Title=Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}