{{Rsnum
|rsid=6690993
|Chromosome=1
|position=59238310
|Orientation=plus
|GMAF=0.3627
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 54.2 | 35.6 | 10.2
| HCB | 55.8 | 37.2 | 7.0
| JPT | 42.2 | 44.4 | 13.3
| YRI | 10.2 | 54.2 | 35.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 55.8 | 37.2 | 7.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs6690993]] is one of 6 SNPs found upstream of an (uncharacterized) gene known as FLJ10986 that have been found to be overrepresented in patients with sporadic amyotrophic lateral sclerosis ([[ALS]]). 

A genome-wide association study of 1,152 [[ALS]] patients determined an allelic odds ratio of 1.35 for the [[rs6690993]](G) allele (CI: 1.13-1.62, p=3x10<sup>-4</sup>). This association was seen only in Caucasians upon replication and not in non-Caucasians. The genotypic odds ratio presented were 1.69 (CI: 1.16-2.47) and 1.2 (CI: 0.81-1.71) for homozygotes and heterozygotes, respectively.{{PMID|17671248}}

* Note: this SNP is in strong linkage disequilibrium with [[rs6700125]] (r<sup>2</sup>>0.8)

{{PMID|19177248}} A study involving a large case-control series from the Netherlands, Belgium, Sweden and Ireland (total: 1883 sporadic ALS patients and 2063 controls) found no significant association between sporadic ALS and the six previously reported associated SNPs, including this one.

{{omim
|desc=AMYOTROPHIC LATERAL SCLEROSIS 1; ALS1
|id=105400
|rsnum=6690993
}}

{{omim
|desc=FLJ10986
|id=611370
|rsnum=6690993
}}

{{PMID Auto
|PMID=19922138
|Title=Analysis of FGGY as a risk factor for sporadic amyotrophic lateral sclerosis
}}

{{PMID Auto
|PMID=22795786
|Title=No association of five candidate genetic variants with amyotrophic lateral sclerosis in a Chinese population
}}

{{PMID Auto
|PMID=24439956
|Title=The single-nucleotide polymorphism rs6690993 in FGGY is not associated with amyotrophic lateral sclerosisin a large Chinese cohort
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}