{{Rsnum
|rsid=6696981
|Chromosome=1
|position=22376365
|Orientation=plus
|GMAF=0.1809
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 71.7 | 27.4 | 0.9
| HCB | 56.2 | 40.1 | 3.6
| JPT | 62.5 | 34.8 | 2.7
| YRI | 42.9 | 48.3 | 8.8
| ASW | 63.2 | 33.3 | 3.5
| CHB | 56.2 | 40.1 | 3.6
| CHD | 65.7 | 29.6 | 4.6
| GIH | 79.2 | 18.8 | 2.0
| LWK | 53.2 | 37.6 | 9.2
| MEX | 91.4 | 8.6 | 0.0
| MKK | 51.6 | 40.0 | 8.4
| TSI | 80.4 | 18.6 | 1.0
| HapMapRevision=28
}}rs6696981 increases susceptibility to Bone mineral density variations, lower for carriers of the G allele {{PMID|18445777}}

rs6696981 increases susceptibility to Osteoporotic fractures for carriers of the G allele {{PMID|18445777}}

{{PMID Auto GWAS
|PMID=19079262
|Trait=Bone mineral density (spine)
|Title=New sequence variants associated with bone mineral density
|RiskAllele=G
|Pval=2E-8
|OR=0.12
|ORtxt=[0.08-0.16] SD decrease
}}

{{PharmGKB
|RSID=rs6696981
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19079262; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: New sequence variants associated with bone mineral density. (Initial Sample Size: 6,865 individuals; Replication Sample Size: 8,510 individuals); (Region: 1p36.12; Reported Gene(s): Intergenic; Risk Allele: rs6696981-G); (p-value= 0.00000002).This variant is associated with Bone mineral density (spine).
|Drugs=
|Drug Classes=
|Diseases=Bone Diseases; Bone Diseases, Metabolic
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740142
}}

{{PMID Auto
|PMID=22824048
|Title=Opposite associations of osteoprotegerin and ZBTB40 polymorphisms with bone mineral density of the hip in postmenopausal Taiwanese women
}}

{{PMID Auto
|PMID=19181680
|Title=Common variants in the region around Osterix are associated with bone mineral density and growth in childhood.
|OA=1
}}

{{PMID Auto
|PMID=19629617
|Title=Replication study of candidate genes/loci associated with osteoporosis based on genome-wide screening.
|OA=1
}}

{{PMID Auto
|PMID=20554715
|Title=Analysis of recently identified osteoporosis susceptibility genes in Han Chinese women.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6696981
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=18
|n_genomes_annotated=0
|n_haplomes=20
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}