{{Rsnum
|rsid=6698181
|Chromosome=1
|position=88677622
|Orientation=plus
|GMAF=0.2975
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene=PKN2-AS1
|Gene_s=PKN2-AS1
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 36.0 | 55.0 | 9.0
| HCB | 39.7 | 46.3 | 14.0
| JPT | 31.0 | 56.6 | 12.4
| YRI | 89.8 | 9.5 | 0.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 39.7 | 46.3 | 14.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 59.4 | 37.6 | 3.0
| LWK | 82.4 | 17.6 | 0.0
| MEX | 36.8 | 47.4 | 15.8
| MKK | 90.3 | 9.7 | 0.0
| TSI | 50.5 | 41.6 | 7.9
| HapMapRevision=28
}}{{Report GE
|PubMed=17463246
|Source=lit
|AffyProbeset=SNP_A-2129780
|AffyOrientation=same
|AlleleA=C
|AlleleB=T
|onGW5=1
|rsid=6698181
|ancestral=C
|RiskPopulation=NEU
|RiskAllele=T
|CaseFreq=
|ControlFreq=0.29
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.11
|Disease=Type II Diabetes
|DiseaseSymbol=T2D
}}

rs6698181 increases susceptibility to Type II Diabetes 1.11 times for carriers of the T allele {{PMID|17463246}}

{{PharmGKB
|RSID=rs6698181
|Name_s=
|Gene_s=PKN2
|Feature=
|Evidence=PubMed ID:17463246
|Annotation=rs6698181 demonstrated association with Type 2 Diabetes in a GWAS of Finnish and Swedish patients and controls.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162168109
}}

{{PMID Auto
|PMID=18443202
|Title=Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
|OA=1
}}

{{PMID Auto
|PMID=21084393
|Title=Type 2 diabetes (T2D) associated polymorphisms regulate expression of adjacent transcripts in transformed lymphocytes, adipose, and muscle from Caucasian and African-American subjects.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6698181
|overall_frequency_n=27
|overall_frequency_d=128
|overall_frequency=0.210938
|n_genomes=21
|n_genomes_annotated=0
|n_haplomes=23
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}