{{Rsnum
|rsid=6733839
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Chromosome=2
|position=127135234
|Orientation=plus
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}[[rs6733839]] is a [[SNP]] in the bridging integrator 1 [[BIN1]] gene.

[[BIN1]] is a well established risk gene for Alzheimer's disease which was recently confirmed in the International Genomics of Alzheimer's Project (IGAP) study.  

This SNP has a population attributable fraction for AD of 8.1 which is second only to APOE4's of 27.3.
The minor allele T is the risk allele with an associated odds ratio of 1.22 (1.18–1.25) and P-value = 7 x 10^^-44.
http://www.genome.gov/GWASStudySNPS.cfm?id=7523 

[[rs6733839]] and [[rs744373]] are less than 2,000 base pairs apart,and they have similar ORs and MAFs. Therefore, it seems reasonable to suspect that these 2 SNPs are actually reporting the same signal.

rs744373	rs6733839	1805	0.580	0.909	None	chr2	127609280

This line is taken from the SNAP file for rs744373 http://www.broadinstitute.org/mpg/snap/ldsearch.php . The first two entries identify the SNPs, then the base pair distance between them, their r^^2, DPrime, arrays present on, chromosome number, and the location.   




{{PMID|24443964}} Review: The genetics of Alzheimer's disease; putting flesh on the bones
{{PMID Auto GWAS
  |PMID=24162737
  |Trait=Alzheimer's disease (late onset)
  |Title=Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease.
  |RiskAllele=T
  |Pval=7E-44
  |OR=1.22
  |ORtxt=[1.18-1.25]
  }}