{{Rsnum
|rsid=673548
|Gene=APOB
|Chromosome=2
|position=21014672
|Orientation=plus
|GMAF=0.3485
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=APOB
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 6.2 | 28.6 | 65.2
| HCB | 50.0 | 42.6 | 7.4
| JPT | 45.1 | 45.1 | 9.7
| YRI | 5.5 | 37.7 | 56.8
| ASW | 1.8 | 39.3 | 58.9
| CHB | 50.0 | 42.6 | 7.4
| CHD | 61.1 | 28.7 | 10.2
| GIH | 28.0 | 50.0 | 22.0
| LWK | 2.8 | 26.9 | 70.4
| MEX | 3.4 | 37.9 | 58.6
| MKK | 5.8 | 28.6 | 65.6
| TSI | 6.9 | 36.3 | 56.9
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060910
|Trait=Other metabolic traits
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
|RiskAllele=A
|Pval=2E-8
|OR=0.08
|ORtxt=[0.05-0.11] mmol/l decrease
|OA=1
}}

{{PharmGKB
|RSID=rs673548
|Name_s=
|Gene_s=APOB
|Feature=Intron
|Evidence=PubMed ID:19060910; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (Initial Sample Size: 4,763 individuals; Replication Sample Size: NR); (Region: 2p24.1; Reported Gene(s): APOB; Risk Allele: rs673548-A); (p-value= 0.00000002).This variant is associated with Other metabolic traits.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740289
}}

{{PMID Auto GWAS
|PMID=22399527
|Trait=None
|Title=Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.
|RiskAllele=G
|Pval=1E-10
|OR=0.1100
|ORtxt=None
|OA=1
}}

{{PMID|18296645|OA=1
}} Polymorphisms of genes in the lipid metabolism pathway and risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China.

{{PMID|19060911|OA=1
}} Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.

{{PMID|19474294|OA=1
}} Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

{{PMID|19936222|OA=1
}} Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.

{{PMID|20502693|OA=1
}} Genetics and beyond--the transcriptome of human monocytes and disease susceptibility.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs673548
|overall_frequency_n=31
|overall_frequency_d=128
|overall_frequency=0.242188
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22916037
  |Trait=Metabolite levels
  |Title=Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
  |RiskAllele=
  |Pval=1E-13
  |OR=NR
  |ORtxt=NR
  |OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}