{{Rsnum
|rsid=6749447
|Gene=STK39
|Chromosome=2
|position=168184876
|Orientation=plus
|GMAF=0.4619
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=STK39
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 4.6 | 47.7 | 47.7
| HCB | 53.3 | 35.6 | 11.1
| JPT | 52.3 | 38.6 | 9.1
| YRI | 30.2 | 58.7 | 11.1
| ASW | 0.0 | 0.0 | 0.0
| CHB | 53.3 | 35.6 | 11.1
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
[[rs6749447]] is a SNP in the serine threonine kinase 39 [[STK39]] gene.

A study of ~1,000 Amish originally identified [[rs6749447]] and another SNP also in the [[STK39]] gene, [[rs3754777]], as being significantly associated with [[hypertension]]. This association was then found to also hold in patient data analyzed from the Framingham Heart Study and the Diabetes Genetics Initiative. On average, each minor allele, in this case [[rs6749447]](G), is associated with 2.0 mmHg higher systolic blood pressure and a 1.0 mm Hg higher diastolic pressure.{{doi|10.1073/pnas.0808358106}}

{{PMID Auto GWAS
|PMID=19114657
|Trait=Blood pressure
|Title=Whole-genome association study identifies STK39 as a hypertension susceptibility gene
|RiskAllele=G
|Pval=2E-7
|OR=1.90
|ORtxt=[1.2-2.6] mm Hg increase in DBP
|OA=1
}}

{{PharmGKB
|RSID=rs6749447
|Name_s=
|Gene_s=STK39
|Feature=
|Evidence=PubMed ID:19114657; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Whole-genome association study identifies STK39 as a hypertension susceptibility gene. (Initial Sample Size: 542 individuals; Replication Sample Size: 6,583 individuals); (Region: 2q24.3; Reported Gene(s): STK39; Risk Allele: rs6749447-G); (p-value= 0.0000002).This variant is associated with Blood pressure.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740097
}}
{{PMID Auto
|PMID=20003416
|Title=STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression
|OA=1
}}

{{PMID Auto
|PMID=21993215
|Title=STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men
}}
{{PMID Auto
|PMID=21228780
|Title=Novel genetic variations associated with salt sensitivity in the Korean population.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6749447
|overall_frequency_n=62
|overall_frequency_d=128
|overall_frequency=0.484375
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=54
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23151749
|Title=Lack of association between STK39 and hypertension in the Chinese population
}}

{{PMID Auto
|PMID=23235358
|Title=A functional variant in the serine-threonine kinase coding gene is associated with hypertension:  a case-control study in a Finnish population, the Tampere adult population cardiovascular risk study
}}

{{PMID Auto
|PMID=23408757
|Title=Association between Serine/Threonine Kinase 39 Gene Polymorphism, Hypertension, and Other Cardiovascular Risk Factors in Koreans
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}