{{Rsnum
|rsid=679620
|Gene=MMP3
|Chromosome=11
|position=102842889
|Orientation=minus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3714
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MMP3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 31.8 | 52.7 | 15.5
| HCB | 13.3 | 35.6 | 51.1
| JPT | 6.8 | 40.9 | 52.3
| YRI | 11.1 | 55.6 | 33.3
| ASW | 10.9 | 52.7 | 36.4
| CHB | 13.3 | 35.6 | 51.1
| CHD | 15.2 | 44.8 | 40.0
| GIH | 7.1 | 38.8 | 54.1
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 9.2 | 44.4 | 46.4
| TSI | 24.5 | 50.0 | 25.5
| HapMapRevision=28
}}

A study of 1418 African-American women and men from the Genetic Epidemiology Network of Arteriopathy study found a significant sex-specific interaction effect between [[rs679620]], a SNP in the metallopeptidase 3 [[MMP3]] gene and body mass index (BMI) in African-American women but not men (p = 0.0009). [[rs679620]] appears to have a protective effect on diastolic blood pressure in women with high BMI, but  surprisingly, it had the opposite effect on women with low BMI, resulting in higher diastolic BP.{{PMID|19008710|OA=1
}}

{{PMID|19042922}} A relatively small study (~100 patients) found associations between risk for [[Achilles tendinopathy]] and SNPs in the [[MMP3]] gene. For [[rs679620]], the (G;G) genotype had an odds ratio of 2.5 (CI: 1.2 - 4.90, p = 0.010). An interaction resulting in increased risk for Achilles tendinopathy was also reported between the [[rs679620]](G) and COL5A1 [[rs12722]](T) alleles (p = 0.006).

{{PMID Auto
|PMID=21753786
|Title=Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis.
}}

{{PMID Auto
|PMID=15748780
|Title=Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease.
}}

{{PMID Auto
|PMID=18303200
|Title=Matrix metalloproteinase-3 genotypes influence recovery from hepatitis B virus infection.
|OA=1
}}

{{PMID Auto
|PMID=18636124
|Title=Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma.
|OA=1
}}

{{PMID Auto
|PMID=18727828
|Title=Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study.
|OA=1
}}

{{PMID Auto
|PMID=19064570
|Title=Missense polymorphisms in matrix metalloproteinase genes and skin cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19318431
|Title=No association between matrix metalloproteinase-1 or matrix metalloproteinase-3 polymorphisms and breast cancer susceptibility: a report from the Shanghai Breast Cancer Study.
|OA=1
}}

{{PMID Auto
|PMID=19406964
|Title=Association of genetic variants with chronic kidney disease in Japanese individuals.
|OA=1
}}

{{PMID Auto
|PMID=19435861
|Title=No association between matrix metalloproteinase (MMP)-1, MMP-3, and MMP-7 SNPs and endometrial cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19487301
|Title=Genetic and environmental risks for high blood pressure among African American mothers and daughters.
|OA=1
}}

{{PMID Auto
|PMID=19551141
|Title=Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.
|OA=1
}}

{{PMID Auto
|PMID=19729601
|Title=Candidate gene polymorphisms for ischemic stroke.
|OA=1
}}

{{PMID Auto
|PMID=20359947
|Title=A functional variant within the MMP3 gene does not associate with human range of motion.
}}

{{PMID Auto
|PMID=20622166
|Title=Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.
|OA=1
}}

{{PMID Auto
|PMID=21410539
|Title=Matrix metalloproteinase genes on chromosome 11q22 and the risk of anterior cruciate ligament (ACL) rupture.
}}

{{PMID Auto
|PMID=22175304
|Title=Matrix metalloproteinase-3 gene polymorphisms are associated with ischemic stroke.
}}

{{PMID Auto
|PMID=22515887
|Title=Genetic susceptibility to periapical disease: conditional contribution of MMP2 and MMP3 genes to the development of periapical lesions and healing response.
|OA=1
}}

{{GET Evidence
|gene=MMP3
|aa_change=Lys45Glu
|aa_change_short=K45E
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs679620
|overall_frequency_n=5896
|overall_frequency_d=10758
|overall_frequency=0.548057
|n_genomes=47
|n_genomes_annotated=0
|n_haplomes=65
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=22776467
|Title=Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A(VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes
}}

{{PMID Auto
|PMID=23926017
|Title=[Association of matrix metalloproteinase-3 gene polymorphisms with subtypes of ischemic stroke]
}}

{{PMID Auto
|PMID=21859746
|Title=Genetic and BMI risks for predicting blood pressure in three generations of West African Dogon women.
|OA=1
}}

{{PMID Auto
|PMID=22671570
|Title=MMP3 and TIMP1 variants contribute to chronic periodontitis and may be implicated in disease progression.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}