{{Rsnum
|rsid=680244
|Gene=CHRNA5
|Chromosome=15
|position=78578946
|Orientation=minus
|GMAF=0.3274
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CHRNA5
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 21.2 | 39.8 | 38.9
| HCB | 5.8 | 39.4 | 54.7
| JPT | 0.9 | 29.2 | 69.9
| YRI | 19.7 | 40.1 | 40.1
| ASW | 15.8 | 45.6 | 38.6
| CHB | 5.8 | 39.4 | 54.7
| CHD | 4.6 | 36.7 | 58.7
| GIH | 8.9 | 44.6 | 46.5
| LWK | 14.5 | 52.7 | 32.7
| MEX | 10.3 | 24.1 | 65.5
| MKK | 12.2 | 51.9 | 35.9
| TSI | 9.9 | 50.5 | 39.6
| HapMapRevision=28
}}{{PharmGKB
|RSID=rs680244
|Name_s=
|Gene_s=CHRNA5
|Feature=
|Evidence=PubMed ID:18618000
|Annotation=This SNP is not associated with dichotomy in the severity of early onset nicotine addiction, as assessed by the FTND (Fagerstrom Test of Nicotine Dependence). Haplotype B, which contains this SNP, is also not associated with this phenotype.
|Drugs=nicotine
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162168242
}}

{{PMID Auto
|PMID=16314871
|Title=Why do young women smoke? I. Direct and interactive effects of environment, psychological characteristics and nicotinic cholinergic receptor genes.
}}

{{PMID Auto
|PMID=17373692
|Title=No evidence for association between 19 cholinergic genes and bipolar disorder.
|OA=1
}}

{{PMID Auto
|PMID=18163978
|Title=The CHRNA5/A3/B4 gene cluster variability as an important determinant of early alcohol and tobacco initiation in young adults.
|OA=1
}}

{{PMID Auto
|PMID=18519524
|Title=Variants in nicotinic receptors and risk for nicotine dependence.
|OA=1
}}

{{PMID Auto
|PMID=19064933
|Title=Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans.
|OA=1
}}

{{PMID Auto
|PMID=19436041
|Title=Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=19443489
|Title=Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
|OA=1
}}

{{PMID Auto
|PMID=19706762
|Title=The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.
|OA=1
}}

{{PMID Auto
|PMID=20700436
|Title=Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
|OA=1
}}

{{PMID Auto
|PMID=20808433
|Title=Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.
|OA=1
}}

{{PMID Auto
|PMID=21268243
|Title=Markers in the 15q24 nicotinic receptor subunit gene cluster (CHRNA5-A3-B4) predict severity of nicotine addiction and response to smoking cessation therapy.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs680244
|overall_frequency_n=86
|overall_frequency_d=128
|overall_frequency=0.671875
|n_genomes=48
|n_genomes_annotated=0
|n_haplomes=76
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}