{{Rsnum
|rsid=6832769
|Gene=CLOCK
|Chromosome=4
|position=55432027
|Orientation=plus
|GMAF=0.2998
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|gene=CLOCK
|Gene_s=CLOCK
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 39.3 | 50.0 | 10.7
| HCB | 43.8 | 47.4 | 8.8
| JPT | 61.9 | 33.6 | 4.4
| YRI | 61.2 | 32.7 | 6.1
| ASW | 49.1 | 45.6 | 5.3
| CHB | 43.8 | 47.4 | 8.8
| CHD | 48.1 | 44.4 | 7.4
| GIH | 72.3 | 27.7 | 0.0
| LWK | 57.8 | 38.5 | 3.7
| MEX | 48.3 | 41.4 | 10.3
| MKK | 51.3 | 44.2 | 4.5
| TSI | 44.4 | 38.4 | 17.2
| HapMapRevision=28
}}

{{PMID|18957941|OA=1
}} The A allele of the [[CLOCK]] gene SNP [[rs6832769]] was associated with lessened [[personality_traits|agreeableness]] (p = 0.00000871) in a group of 3972 Sardinians. The effect remained significant in the replicative American sample, but failed to achieve significance in the Norwegian sample and third sample (though the combined p value remained significant at 0.000865). [http://people.virginia.edu/~wc9c/publications/pdf/mp2008113a.pdf full paper in pdf]

{{PharmGKB
|RSID=rs6832769
|Name_s=
|Gene_s=CLOCK
|Feature=
|Evidence=PubMed ID:18957941; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association scan for five major dimensions of personality. (Initial Sample Size: 3,972 individuals; Replication Sample Size: 3,903 individuals); (Region: 4q12; Reported Gene(s): CLOCK; Risk Allele: rs6832769-A); (p-value= 0.000002).This variant is associated with Personality dimensions.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740321
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs6832769
|overall_frequency_n=95
|overall_frequency_d=128
|overall_frequency=0.742188
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=80
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}