{{Rsnum
|rsid=683395
|Gene=LAMP3
|Chromosome=3
|position=183152030
|Orientation=minus
|GMAF=0.1175
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=LAMP3
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 18.6 | 81.4
| HCB | 2.9 | 17.5 | 79.6
| JPT | 0.9 | 18.6 | 80.5
| YRI | 6.1 | 28.6 | 65.3
| ASW | 0.0 | 31.6 | 68.4
| CHB | 2.9 | 17.5 | 79.6
| CHD | 1.8 | 15.6 | 82.6
| GIH | 0.0 | 15.8 | 84.2
| LWK | 5.5 | 25.5 | 69.1
| MEX | 0.0 | 12.1 | 87.9
| MKK | 7.7 | 42.3 | 50.0
| TSI | 0.0 | 14.7 | 85.3
| HapMapRevision=28
}}
[[rs683395]] has been reported in a large study to be associated with [[bipolar disorder]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.47 (CI 1.26-1.71), and for homozygotes, 1.3 (CI 0.69-2.46). {{PMID|17554300|OA=1
}}

{{GWAS Summary
|SNP=rs683395
|PubMedID=17554300
|Condition=Bipolar disorder
|Gene=NR
|Risk Allele=G
|pValue=5.00E-006
|OR=1.47
|95CI=1.26-1.71
|OA=1
}}

{{PharmGKB
|RSID=rs683395
|Name_s=
|Gene_s=LAMP3
|Feature=
|Evidence=PubMed ID:17554300; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls (Initial Sample Size: 1,868 cases, 2,938 controls; Replication Sample Size: NR; Risk Allele: rs683395-G). This variant is associated with bipolar disorder.
|Drugs=
|Drug Classes=
|Diseases=Bipolar Disorder
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356655
}}

{{PMID|19308021|OA=1
}} Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs683395
|overall_frequency_n=110
|overall_frequency_d=128
|overall_frequency=0.859375
|n_genomes=54
|n_genomes_annotated=0
|n_haplomes=92
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}